Institute of Microbial Technology
Regional Center for Biotechnology, Faridabad
Molecular Biology of Infectious and Idiopathic Inflammation
Research in my lab is broadly directed at understanding the key events that cause inflammation during infection and autoimmune disorders. Uncontrolled inflammation contributes to the pathogenesis of inflammatory diseases as well as the development of cancers. We use Salmonella in cell culture and mouse system with the key objective to understand molecular mechanism underlying the observed inflammation.
The gram negative, facultative intracellular bacterial pathogen Salmonella is one of the most frequent causes of acute gastroenteritis in humans. The disease results from a complex cascade of interactions between the pathogenic bacterium, the host intestinal epithelium, the commensal microbiota and the immune system of the host. The disease manifestation is characterized histologically by massive infiltration of neutrophils (PMN), a phenotype also observed in some of the chronic recurrent inflammatory disorders with unknown etiology such as Crohn's disease (CD) and ulcerative colitis (UC).
Our recent paradigm shifting discovery, demonstrating host-SUMOylation mahcinary perturbation by Salmonella using miRNAs has opened several new exciting avenues in biology of infectious diseases. Using state of the art tools of microbiology, molecular biology and fluorescent-imaging we envisage to carry out host-pathogen interaction studies. The ultimate goal is not only to combat bacterial pathogenesis but also find therapeutic solutions to auto-immune disorders.