Indian Institute of Science, Bangalore
Indian Institute of Science Education and Research, Kolkata
My journey of scientific discovery began with an exposure to the intricacies of human physiology and biochemistry at the Presidency College, Kolkata, where I obtained an undergraduate degree. Following this, I joined the Integrated PhD programme at the Indian Institute of Science Bangalore, where my horizon was vastly broadened, developing an understanding of biology from the atomic to the organismal, which has possibly left its imprint on all my subsequent research. I obtained a doctoral degree in molecular virology from IISc. Bangalore in 2005, with my PhD thesis focused on investigating the regulation of translation in RNA viruses. Translation regulation has been my abiding interest since then. During my pre-doctoral work at IISc. Bangalore, I also discovered the internal ribosome entry site-mediated translation of p53, which was shown to cause regulated expression of p53, and of a truncated isoform (p47), in a cell cycle-dependent manner. Thereafter, I joined the department of Cell Biology at the Lerner Research Institute of the Cleveland Clinic in Cleveland, Ohio, USA. During my post-doctoral work at the Cleveland Clinic I began to investigate the translational regulation of inflammatory and cancer-related genes. My work led to the discovery of the first mammalian riboswitch regulating the expression of the critical tumor angiogenesis protein VEGF in inflammatory macrophages. I joined the department of Biological Sciences at the Indian Institute of Science Education and Research, Kolkata in 2008 where I am currently an Assistant Professor. My current research is focused on investigating the interplay between microRNA and RNA-binding proteins in the translation regulation of inflammatory genes. My group is using molecular and system biology approaches to understand such interplay both at the level of candidate genes and that of the whole transcriptome. Together with this, I am studying the molecular evolution of protein domains, especially those of RNA-binding proteins that are involved in the inflammatory response.