University of Frankfurt, Germany
Department of Microbiology and Cell Biology (MCB), Indian Institute of Science (IISc), Bangalore
In a true sense I was exposed to the life science during my undergrad days at the University of Delhi. I started understanding biological phenomenon and related principles during that time and thus inclined in pursuing my career in life science. For masters, I joined the Department of Plant Molecular Biology (PMB), South Campus and there I learned most of the exciting work conducted in the field of of molecular biology and cellular biology. Excellent training of PMB led me to pursue my PhD in the laboratory of Prof. Lutz Nover (University of Frankfurt, Germany). In Lutz's laboratory, I initially characterized Arabidopsis heat shock transcription factors and later discovered developmental potential of such transcription factors during seed development in Arabidopsis. Those were pretty excited days as studying gene function by RNAi or exploring the transcriptome became a routine job. There, I also got acquainted with totally divergent themes of life science including asymmetric cell division (ACD). Towards the last year of my PhD, I was pretty convinced that I want to pursue my postdoctoral work in the field of ACD. Therefore, I joined the laboratory of Prof. Pierre Gönczy to contribute to uncover the mechanisms governing spindle positioning during ACD of C. elegans embryos. Unfortunately or fortunately the problem that I wanted to tackle using C. elegans embryos as a model system did not translate into any rewarding outcome, however, this allowed me to master the system and learn the tricks and techniques of such a beast. In parallel, I established human cells-based system to dissect spindle positioning during mitotic progression. This allowed me to discover some of the exciting questions related with spatiotemporal dynamics of mitotic spindle positioning in human cells.
Since May 2015, I am working in the Department of Microbiology and Cell Biology (MCB) at the Indian Institute of Science (IISc). Major goal of my laboratory is to unravel the mechanisms by which mitotic spindle behavior is orchestrated in time and space in human cells and in C. elegans embryos. Because this process is fundamental for life, discoveries made in this direction will be crucial not only in the realm of basic science but also in the context of applied science including tumorgenesis and regenerative medicine.