CSIR-Institute of Genomics and Integrative Biology, Delhi, India
All India Institute of Medical Sciences, New Delhi, India
While attending medical school at Government Medical College, Amritsar, I was baffled by the complexity of health and disease. Motivated to research and understand these, I enrolled into the Ph.D. program at CSIR-Institute of Genomics and Integrative Biology. The excellent scientific environment introduced me to the fascinating world of scientific inquiry beyond disciplines and to think quantitatively about medicine. The overarching theme of my Ph.D. work was to resolve the health-spectrum through integration of physiology and genomics.The biological motivation behind many artificial-intelligence algorithms inspired me to develop quantitative algorithmic thinking and I developed a sensitive novel marker of small airway diseases through a “lung-physiology inspired” mathematical model. Early small airway disease is notoriously difficult to detect using conventional techniques and the exquisite detection ability of this novel index led to the MIT-India Young Innovator Award, 2013. This natural progression from “Research” to “Translational Research” continues to be the major driving forces of my current research. After completion of Ph.D., I worked as a Quick Hire Scientist Fellow at the CSIR-Fourth Paradigm Institute (erstwhile Centre for Mathematical Modeling and Computer Simulation) with a focus on developing actionable network models on Big Data for Public Health. I was also a co-investigator in Indo-US Grand Challenge project on developing a low cost device for rapid monitoring of Blood Pressure and created machine learning models for the same. With the unique fellowship programs of Wellcome Trust/DBT India Alliance, my passion to integrate computation and medicine became a reality. Supported by the India Alliance, we have initiated our Sepsis Advanced Forecasting Engine (SAFE-ICU) project which is a unique machine learning-clinical science effort. Through this project, we hope to decrease mortality in babies and children by early detection and stratification of sepsis, a devastating condition in Pediatric and Neonatal Intensive Care Units.
The IA fellowship has allowed me to work in a clinically stimulating environment at All India Institute of Medical Sciences (AIIMS-New Delhi), Indraprastha Institute of Information Technology (IIIT-Delhi) and in future at Stanford School of Medicine.