Publications and Presentations

1)            Daniel B, Rangarajan A, Mukherjee G, Vallikad E, Krishna S.(1997). The Link Between Integration and Expression of Human Papillomavirus Type 16 Genomes and Cellular Changes in the Evolution of Cervical Intraepithelial Neoplastic Lesions. J Gen Virol. 78 ( Pt 5):1095-10

2)            Krishna S., Syal R, Mythily DV, Tergaonkar V. & Rangarajan A. (1998). The role of the Notch Pathway in Viral Induced Oncogenesis. Proceedings of the second ICGEB-UCI Virology Symposium

3)            Rangarajan A, Syal R, Selvarajah S, Chakrabarti O, Sarin A and Krishna S. (2001). Activated Notch1 Signaling Co-operates with Papillomavirus Oncogenes in Transformation and Generates Resistance to Apoptosis on Matrix Withdrawal Through PKB/Akt. Virology 286(1), 23-30.

4)            Rangarajan A, Talora C, Nicolas M, Okuyama R, Mammucari C, Oh H, Aster JC, Krishna S, Metzger D, Chambon P, Miele L, Aguet M, Radtke F and G. Dotto GP. (2001). Notch1 Functions as a Direct Determinant of the Exit of Keratinocytes from the Cell Cycle and Entry into Differentiation. EMBO J. 20(13), 3427-36.

5)            Veeraraghavalu K, Pett M, Kumar RV, Nair P, Rangarajan A, Stanley MA, Krishna S. (2004). Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. J Virol. Aug;78(16):8687-700.

6)            Rangarajan A, Hong SJ and Weinberg RA. (2004). Species- and Cell Type- Specific Requirements for Cellular Transformation. Cancer Cell 2004 Aug;6(2):171-83.

7)            Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A. (2006). Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J Immunol Oct 15;177(8):5041-50.

8)            Dey D, Saxena M, Paranjape AN, Krishnan V, Giraddi R, Vijaya Kumar M, Mukherjee G, and Rangarajan A. (2009). Phenotypic and Functional Characterization of Human Mammary Stem/progenitor Cells in Long Term Culture PLoS ONE. 02/2009; 4(4):e5329.

9)            Kumar HS and Rangarajan A. (2009). SV40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation. J Virol. Sep;83(17):8565-74.

10)         Mittal S, Subramanyam D, Dey D, Kumar RV, and Rangarajan A. (2009). Cooperation of Notch and Ras/MAPK Signaling Pathways in Human Breast Carcinogenesis. Molecular Cancer, 8:128.

11)         Saxena M, Mary Ann S, Pathak H, and Rangarajan A. (2011). Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters. Cell Death Dis  Jul 7;2:e179. doi: 10.1038/cddis.2011.61

12)         Paranjape, A.N., Mandal, T., Mukherjee G., Vijaya Kumar, M., Sengupta K. and Rangarajan, A. (2012). Introduction of SV40ER and hTERT into mammospheres generates breast cancer cells with stem cell properties. Oncogene, Apr 12;31(15):1896-909.

13)         Arya N, Sardana V, Saxena M, Rangarajan A, Katti DS. (2012). Recapitulating tumour microenvironment in chitosan-gelatin three-dimensional scaffolds: an improved in vitro tumour model. J R Soc Interface. Dec 7;9(77):3288-302. doi: 10.1098/rsif.2012.0564.

14)         Sharma A, Paranjape AN, Rangarajan A, Dighe RR. A monoclonal antibody against human Notch1 ligand-binding domain depletes subpopulation of putative breast cancer stem-like cells (2012). Mol Cancer Ther. Jan;11(1):77-86.

15)         Sharma A, Rangarajan A, Dighe RR. (2013). Antibodies against the extracellular domain of human Notch1 receptor reveal the critical role of epidermal-growth-factor-like repeats 25-26 in ligand binding and receptor activation. Biochem J. Jan 15;449(2):519-30.

16)         Naseer M, Udupa N,  Pai K. S. R, Rangarajan A. (2013).  Extracts of Withania somnifera and Tinospora cordiofolia induce apoptosis in human breast cancer cells. International Journal of Applied Research in Natural Products. Vol. 6 (4), pp. 1-10.

17)         Hindupur SK, Balaji AS, Saxena M, Pandey S, Sravan GS, Heda N, Kumar MV, Mukherjee G, Dey D, and Rangarajan A (2014). Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells. Breast Cancer Research Aug 6;16(4):420.

18)         Paranjape AN, Balaji SA, Mandal T, Krushik EV, Nagaraj P, Mukherjee G, Rangarajan A. (2014). Bmi1 regulates self-renewal and epithelial to mesenchymal transition in breast cancer cells through Nanog. BMC Cancer. 2014 Oct 28;14:785. doi: 10.1186/1471-2407-14-785.

19)         Mittal S, Sharma A, Balaji SA, Gowda MC, Dighe RR, Kumar RV, Rangarajan A (2014). Coordinate hyperactivation of Notch1 and Ras/MAPK pathways correlates with poor patient survival: novel therapeutic strategy for aggressive breast cancers. Mol Cancer Ther. Dec;13(12):3198-209. doi: 10.1158/1535-7163.MCT-14-0280.

20)         Naseer M, Beeran AA, Balaji SA, Udupa N, Pai SR, Rangarajan A. Effects of Withania somnifera and Tinospora cordifolia extracts on the side population phenotype of human epithelial cancer cells: Towards targeting multi-drug resistance in cancer. Integr Cancer Ther. December 29, DOI: 10.1177/1534735414564423.

21)         Elumalai R,  Patil S,  Maliyakkal N, Rangarajan A,  Kondaiah P, and  Raichur AM (2015). Protamine-carboxymethyl cellulose magnetic nanocapsules for enhanced delivery of anticancer drugs against drug resistant cancers. Nanomedicine: nanotechnology, biology, and medicine, 2015; May;11(4):969-81. doi: 10.1016/j.nano.2015.01.005. Epub 2015 Feb 7.

22)         Chopra S, Kumar N,  Rangarajan A, and Kondaiah P (2015). Context dependent non canonical WNT signaling mediates activation of fibroblasts by transforming growth factor-β. Experimental cell research doi:10.1016/j.yexcr.2015.03.001.

23)         Sharma A, Gadkari RA, Ramakanth SV, Padmanabhan K, Madhumathi DS, Devi L, Appaji L, Aster JC, Rangarajan A, Dighe RR. A novel monoclonal antibody against notch1 targets leukemia-associated mutant Notch1 and depletes therapy resistant cancer stem cells in solid tumors. Scientific Reports. 2015 Jun 5;5.

24)         Dubey, Abhinav; Rangarajan, Annapoorni; Pal, Debnath; Atreya, Hanudatta. Pattern recognition based approach for identifying metabolites in NMR based metabolomics". Anal. Chem., 2015, 87 (14), pp 7148–7155, June 23.

25)         Abhinav Dubey, Annapoorni Rangarajan, Debnath Pal*, and Hanudatta S. Atreya*. Chemical Shifts to Metabolic Pathways: Identifying Metabolic Pathways Directly from a Single 2D NMR Spectrum. Anal. Chem., 2015, 87 (24), pp 12197–12205, DOI: 10.1021/acs.analchem.5b03082, November 10, 2015 (web publication).

26)         Gowri Manohari Balachander, Sai A. Balaji, Annapoorni Rangarajan*, and Kaushik Chatterjee*. Enhanced Metastatic Potential in a 3D Tissue Scaffold toward a Comprehensive in Vitro Model for Breast Cancer Metastasis. ACS Appl. Mater. Interfaces, Article ASAP. DOI: 10.1021/acsami.5b09064. Publication Date (Web): November 24, 2015 (web publication).*Co-communicating authors.

27)         Ganguly, A., Bhattacharjee, C., Bhave, M., Kailaje, V., Jain, B. K., Sengupta, I., Rangarajan, A. and Bhattacharyya, D. (2016), Perturbation of nucleo-cytoplasmic transport affects size of nucleus and nucleolus in human cells. FEBS Lett. doi:10.1002/1873-3468.12077.

28)         A Sundararaman, U Amirtham, A Rangarajan(2016). Calcium-Oxidant Signaling Network Regulates AMPK Activation Upon Matrix-deprivation. J Biol Chem. 2016 Jul 8;291(28):14410-29. doi: 10.1074/jbc.M116.731257. Epub 2016 May 11.

29)         Balaji SA, Udupa N, Chamallamudi MR, Gupta V, Rangarajan (2016). Role of the Drug Transporter ABCC3 in Breast Cancer Chemoresistance. PLoS One. 2016 May 12;11(5):e0155013. doi: 10.1371/journal.pone.0155013. eCollection 2016.

30)         Saha M, Kumar S, Bukhari S, Balaji SA, Kumar P, Hindupur SK, Rangarajan A. AMPK-AKT double negative feedback loop in breast cancer cells regulates their adaptation to matrix deprivation. Cancer Research. 2018 Jan 1:canres-2090.



General Articles:

30)         Rangarajan A and Weinberg RA. (2003). Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer. Dec;3(12):952-9.

31)         Kusumbe A and Rangarajan A. (2006) Stem cells in Breast Cancer Research. Journal of Mammology, 8, 20-26.

32)         Dey,D., Rangarajan, A (2007). Stem cells: A dormant volcano within our body? Resonance,12, 27-34.

33)         Paranjape, A.N. and Rangarajan A. (2010). How to Protect the Chromosomal Ends?  Resonance 15, 538-547.

34)         Rangarajan A. Cancer Stem Cells: The Real Enemies within Cancer?  (2012). Journal of the Indian Institute of Science. Vol 92:3 Jul.–Sept.

35)         Sonnenschein S, Soto AM, Rangarajan A, Kulkarni P. (2013). Competing Views on Cancer. J Biosciences.

36)         Neha Deshpande, and Annapoorni Rangarajan, “Cancer Stem Cells: Formidable Allies of Cancer,” Indian Journal of Surgical Oncology, 1-15, 2015.



Book Chapters:

1)            Saxena M. and Rangarajan A. (2008). Isolation and Characterization of Breast and Brain Cancer Stem Cells. (Cancer Stem Cells: Identification and Targets. Edited by SA Bapat; Wiley).

2)            Dey,D., Maliyakkal , N., Saxena, M., Paranjape, AN., Rangarajan, A (2009). Cancer stem cells: The enemy within cancers. (Stem cells: Basics and Applications. Edited by Deb KD and Totey SM; Tata McGraw-Hill Education Private Limited).

3)            Dey, D. and Rangarajan, A. (2011). Breast Cancer Stem Cells. (Applications of Flowcytometry in Stem Cell Research and Tissue Regeneration. Edited by A Krishan, H Krishnamurthy, S Totey; Wiley-Blackwell.