Publications and Presentations

1. Mehta M, and Singh A. Mycobacterium tuberculosis WhiB3 maintains redox homeostasis and survival in response to reactive oxygen and nitrogen species. Free Radic Biol Med. 2018 Nov 27(131): 50-58. PubMed PMID: 30500421

2.     Chawla M, Mishra S, Anand K, Parikh P, Mehta M, Vij M, Verma T, Singh P, Jakkala K, Verma HN, AjitKumar P, Ganguli M, Narain Seshasayee AS, and Singh A. Redox-dependent condensation of the mycobacterial nucleoid by WhiB4. Redox Biol.  2018 Aug 13(19): 116-133. PubMed PMID: 30149290.

3.     Pal VK, Bandyopadhyay P, and Singh A. Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses. IUBMB Life. 2018 May 70 (5): 393-410. PubMed PMID: 29601123.

4.    Singh A#, and Surolia A. Tuberculosis: Today's researches-tomorrow's therapies. IUBMB Life. 2018 Sep 70(9): 814-817. PubMed PMID: 30120871. (#Co-corresponding Author).

5.     Libardo MDJ, de la Fuente-Nuñez C, Anand K, Krishnamoorthy G, Kaiser P, Pringle SC, Dietz C, Pierce S, Smith MB, Barczak A, Kaufmann SHE, Singh A#, and Angeles-Boza AM. Phagosomal Copper-Promoted Oxidative Attack on Intracellular Mycobacterium tuberculosis. ACS Infect Dis. 2018 Sep 6. PubMed PMID: 30141623. (#Co-corresponding Author)

6.     Sikri K, Duggal P, Kumar C, Batra SD, Vashist A, Bhaskar A, Tripathi K, Sethi T, Singh A, and Tyagi JS. Multifaceted remodeling by vitamin C boosts sensitivity of Mycobacterium tuberculosis subpopulations to combination treatment by anti-tubercular drugs. Redox Biol. 2018 May 15: 452-466. PubMed PMID: 29413958.

7. Mahadik K, Prakhar P, Rajmani RS, Singh A, and Balaji KN. c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial   Infection by Co-Regulating Bone Morphogenesis Protein and miR27a. Front Immunol. 2018 Feb 1(9): 85. eCollection. PubMed PMID: 29449840. 

8.     Mishra S, Shukla P, Bhaskar A, Anand K, Baloni P, Jha RK, Mohan A, Rajmani RS, Nagaraja V, Chandra N, and Singh A. Efficacy of β-lactam/ β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis. Elife. 2017 May 26(6). pii: e25624. PubMed PMID: 28548640.

9.     Shukla P, Khodade VS, SharathChandra M, Chauhan P, Mishra S, Siddaramappa S, Pradeep BE, Singh A#, and Chakrapani H. "On demand" redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor. Chem Sci. 2017 Jul 8(7): 4967-4972. PubMed PMID: 28959420. (#Co-corresponding Author)

10.  Khan MZ, Bhaskar A, Upadhyay S, Kumari P, Rajmani RS, Jain P, Singh A, Kumar D, Bhavesh NS, and Nandicoori VK. Protein kinase G confers survival advantage to Mycobacterium tuberculosis during latency-like conditions. J Biol Chem. 2017 Sep 292(39): 16093-16108. PubMed PMID: 28821621.

11.  Sambarey A, Devaprasad A, Baloni P, Mishra M, Mohan A, Tyagi P, Singh A, Akshata JS, Sultana R, Buggi S, and Chandra N. Meta-analysis of host response networks identifies a common core in tuberculosis. NPJ Syst Biol Appl. 2017 Feb 10(3): 4. PubMed PMID: 28649431.

12.  Mehta M, Rajmani RS, and Singh A. Mycobacterium tuberculosis WhiB3 Responds to Vacuolar pH-induced Changes in Mycothiol Redox Potential to Modulate Phagosomal Maturation and Virulence. J Biol Chem. 2016 Feb 291(6): 2888-903. PubMed PMID: 26637353.

13.  Padiadpu J, Baloni P, Anand K, Munshi M, Thakur C, Mohan A, Singh A#, and Chandra N. Identifying and Tackling Emergent Vulnerability in Drug-Resistant Mycobacteria. ACS Infect Dis. 2016 Sep 2(9): 592-607. PubMed PMID: 27759382. (#Co-corresponding Author)

14.  Holla S, Prakhar P, Singh V, Karnam A, Mukherjee T, Mahadik K, Parikh P, Singh A, Rajmani RS, Ramachandra SG, and Balaji KN. MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection. PLoS Pathog. 2016 Aug 12(8): e1005814. PubMed PMID: 27532872.

15.  Palmer CS, Henstridge DC, Yu D, Singh A, Balderson B, Duette G, Cherry CL, Anzinger JJ, Ostrowski M, and Crowe SM. Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure. J Immunol. 2016 Jun 196(11): 4437-44. PubMed PMID: 27207806.

16.  Palmer CS, Cherry CL, Sada-Ovalle I, Singh A, and Crowe SM. Glucose Metabolism in T Cells and Monocytes: New Perspectives in HIV Pathogenesis. EBioMedicine. 2016 Apr 6: 31-41. PubMed PMID: 27211546.

17.  Palde PB, Bhaskar A, Pedró Rosa LE, Madoux F, Chase P, Gupta V, Spicer T, Scampavia L, Singh A, and Carroll KS. First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis. ACS Chem Biol. 2016 Jan 11(1): 172-84. PubMed PMID: 26524379.

18.  Bhaskar A, Munshi M, Khan SZ, Fatima S, Arya R, Jameel S, and Singh A. Measuring glutathione redox potential of HIV-1-infected macrophages. J Biol Chem. 2015 Jan 290(2): 1020-38. PubMed PMID: 25406321.

19.  Tyagi P, Dharmaraja AT, Bhaskar A, Chakrapani H, and Singh A. Mycobacterium tuberculosis has diminished capacity to counteract redox stress induced by elevated levels of endogenous superoxide. Free Radic Biol Med. 2015 Jul 84: 344-354. PubMed PMID: 25819161.

20.  Anand A, Verma P, Singh AK, Kaushik S, Pandey R, Shi C, Kaur H, Chawla M, Elechalawar CK, Kumar D, Yang Y, Bhavesh NS, Banerjee R, Dash D, Singh A, Natarajan VT, Ojha AK, Aldrich CC, and Gokhale RS. Polyketide Quinones Are Alternate Intermediate Electron Carriers during Mycobacterial Respiration in Oxygen-Deficient Niches. Mol Cell. 2015 Nov 60(4): 637-50. PubMed PMID: 26585386.

21.  Chandra P, Ghanwat S, Matta SK, Yadav SS, Mehta M, Siddiqui Z, Singh A, and Kumar D. Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages. Sci Rep. 2015 Nov 5: 16320. PubMed PMID: 26541268.

22.  Sharma S, Rajmani RS, Kumar A, Bhaskar A, Singh A, Manivel V, Tyagi AK, and Rao KV. Differential proteomics approach to identify putative protective antigens of Mycobacterium tuberculosis presented during early stages of macrophage infection and their evaluation as DNA vaccines. Indian J Exp Biol. 2015 Jul 53(7): 429-39. PubMed PMID: 26245027

23.  Kumar S, Vendruscolo M, Singh A, Kumar D, and Samal A. Analysis of the hierarchical structure of the B. subtilis transcriptional regulatory network. Mol Biosyst. 2015 Mar 11(3): 930-41. PubMed PMID: 25599335

24.  Bhaskar A, Chawla M, Mehta M, Parikh P, Chandra P, Bhave D, Kumar D, Carroll KS, and Singh A. Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection. PLoS Pathog. 2014 Jan 10(1): e1003902. PubMed PMID: 24497832.

25.  Chawla M, Parikh P, Saxena A, Munshi M, Mehta M, Mai D, Srivastava AK, Narasimhulu KV, Redding KE, Vashi N, Kumar D, Steyn AJ, and Singh A. Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo. Mol Microbiol. 2012 Sep 85(6): 1148-65. PubMed PMID: 22780904.

26.  Karim AF, Chandra P, Chopra A, Siddiqui Z, Bhaskar A, Singh A, and Kumar D. Express path analysis identifies a tyrosine kinase Src-centric network regulating divergent host responses to Mycobacterium tuberculosis infection. J Biol Chem. 2011 Nov 286(46): 40307-19. PubMed PMID: 21953458.

27.  Farhana A, Guidry L, Srivastava A, Singh A, Hondalus MK, and Steyn AJ. Reductive stress in microbes: implications for understanding Mycobacterium tuberculosis disease and persistence. Adv Microb Physiol. 2010 (57): 43-117. PubMed PMID: 21078441.