Publications and Presentations


53: Godbole M, Togar T, Patel K, Dharavath B, Yadav N, Janjuha S, Gardi N, Tiwary K, Terwadkar P, Desai S, Prasad R, Dhamne H, Karve K, Salunkhe S, Kawle D, Chandrani P, Dutt S, Gupta S, Badwe RA, Dutt A*. Up-regulation of the kinase gene SGK1 by progesterone activates the AP-1—NDRG1 axis in both PR-positive and -negative breast cancer cell. J Biol Chem; (In press).

52: Bajaj KP, Nguyen TT…..Dutt A….Jura N, Seshagiri S. Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations. Cancer Cell. 2018; (In press).

51:  Iyer P,, Shrikhande SV, Ranjan M, Joshi A,, Gardi N, Prasad R, Dharavath B,, Thorat R, Salunkhe S,, Sahoo B, Chandrani P, Kore H, Mohanty B, Chaudhari V, Choughule A, Kawle D, Chaudhari P, Ingle A, Banavali S, Gera P, Ramadwar MR,  Prabhash K, Barreto SG, Dutt S, Dutt A*ERBB2 and KRAS Alterations Mediate Response to EGFR Inhibitors in Early Stage Gallbladder Cancer. International Journal of Cancer. 2018. 10.1002/ijc.31916

50:  Salunkhe S, Chandran N, Chandrani P, Dutt A, Dutt S. CytoPred: 7 gene pair metric for AML cytogenetic risk prediction. Briefings in Bioinformatics. 2018; (In press

49:  Balaji SA, Shanmugam A, Chougule A, Sridharan S, Prabhash K, Arya A, Chaubey A, Hariharan A, Kolekar P, Sen M, Ravichandran A, Katragadda S, Sankaran S, Bhargava S, Kulkarni P, Rao S, Sunkavalli C, Banavali S, Joshi A, Noronha V, Dutt A, Bahadur U, Hariharan R, Veeramachaneni V, Gupta V. Analysis of solid tumor mutation profiles in liquid biopsy. Cancer Med. 2018 Sep 27. doi: 10.1002/cam4.1791.

48:  Barreto SG, Dutt A, Sirohi B, Shrikhande SV. Gallbladder cancer: a journey of a thousand steps. Future Oncol. 2018 Jun;14(13):1299-1306. doi: 10.2217/fon-2017-0576.

47:  Veldore VH, Choughule A, Routhu T, Mandloi N, Noronha V, Joshi A, Dutt A, Gupta R, Vedam R, Prabhash K. Validation of liquid biopsy: plasma cell-free DNA testing in clinical management of advanced non-small cell lung cancer. Lung Cancer (Auckl). 2018 Jan 3;9:1-11.

46:  Chatterjee S, Chaubal R, Maitra A, Gardi N, Dutt A, Gupta S, Badwe RA, Majumder PP, Pandey P. Pre-operative progesterone benefits operable breast cancer patients by modulating surgical stress. Breast cancer research and treatment. 2018; 170(2):431-438

45:  Rajendra J, Datta KK, Ud Din Farooqee SB, Thorat R, Kumar K, Gardi N, Kaur E, Nair J, Salunkhe S, Patkar K, Desai S, Goda JS, Moiyadi A,Dutt A, Venkatraman P, Gowda H, Dutt S. Enhanced proteasomal activity is essential for long term survival and recurrence of innately radiation resistant residual glioblastoma cells. Oncotarget. 2018; 9(45):27667-27681.


44     Godbole M, Chandrani P, Gardi N, Dhamne H, Patel K, Yadav N, Gupta S, Badwe R, Dutt A. miR-129-2 mediates down-regulation of progesterone receptor in response to progesterone in breast cancer cells. Cancer Biology & Therapy. 2017 

43     Godbole M,  Sharma K, Badwe R, Gupta S, Dutt AProgesterone suppresses the invasion and migration of breast cancer cells irrespective of their progesterone receptor status. Cellular Oncology. 2017; 40(4):411-417

42      Upadhyay P, Gardi N, Desai S, Chandrani P, Joshi A, Dharavath B, Arora P, Bal M, Nair S, Dutt A. Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 as a candidate to predict metastases. Oral Oncology 73:56-64, 2017

41     Noronha V, Chougule A, Patil VM, Joshi A, Kumar V, Philip DSJ, Banavasi S, Dutt A, Prabhash K. Epidermal growth factor receptor exon 20 mutation in lung cancer: types, incidence, clinical features and impact on treatment. OncoTargets and Therapy. 2017 (In press)

40     Bhat S, Gardi N, Hake S, Kotian N, Sawant S, Kannan S, Parmar V, Desai S, Dutt A, Joshi NN. Impact of intra-tumoral IL17A and IL32 gene expression on T-cell responses and lymph node status in breast cancer patients. Journal of cancer research and clinical oncology2017 May 3. doi: 10.1007/s00432-017-2431-5.

39      Mittra I, Samant U, Sharma S, Raghuram GV, Saha T, Tidke P, Pancholi N, Gupta D, Prasannan P, Gaikwad A, Gardi N, Chaubal R, Upadhyay P, Pal K, Rane B, Shaikh A, Salunkhe S, Dutt S, Mishra PK, Khare NK, Nair NK, Dutt A. Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation. Cell Death Discovery, 2017.3, 17015; doi:10.1038/cddiscovery.2017.15 


38      Chandrani P, Prabhash K, Prasad R, Sethunath V, Ranjan M, Iyer P, Aich J, Dhamne H, Iyer DN, Upadhyay P, Mohanty B, Chandna P, Kumar R,  Joshi A, Noronha V, Patil V, Ramaswamy A, Karpe A, Thorat R,  Chaudhari  P, Ingle A, Choughule A, Dutt A (2016) Drug-sensitive FGFR3 mutations in lung adenocarcinoma. Annals of Oncology.

37      Upadhyay P, Nair S, Kaur E, Aich J, Dani P, Sethunath V, Gardi N, Chandrani P, Godbole M, Sonawane K, Prasad R, Kannan S, Agarwal B, Kane S, Gupta S, Dutt S, Dutt A (2016) Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer. Oncotarget

36      Upadhyay P, Gardi N, Desai S, Sahoo B, Singh A, Togar T, Iyer P, Prasad R, Chandrani P, Gupta S, Dutt A (2016) TMC-SNPdb: an Indian germline variant database derived from whole exome sequences. Database : the journal of biological databases and curation

35      Rekhi B, Upadhyay P, Ramteke MP, Dutt A (2016) MYOD1 (L122R) mutations are associated with spindle cell and sclerosing rhabdomyosarcomas with aggressive clinical outcomes. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

34      Kaur E, Sahu A, Hole AR, Rajendra J, Chaubal R, Gardi N, Dutt A, Moiyadi A, Krishna CM, Dutt S (2016) Unique spectral markers discern recurrent Glioblastoma cells from heterogeneous parent population. Scientific reports 6: 26538

33      Iyer P, Barreto SG, Sahoo B, Chandrani P, Ramadwar MR, Shrikhande SV, Dutt A (2016) Non-typhoidal Salmonella DNA traces in gallbladder cancer. Infectious agents and cancer 11: 12

32      Barreto SG, Dutt A (2016) To improve outcomes of gallbladder cancer we need to better understand it! Hepatobiliary surgery and nutrition 5: 379-381


31      Ramteke MP, Patel KJ, Godbole M, Vyas M, Karve K, Choughule A, Prabhash K, Dutt A (2015) CRE: a cost effective and rapid approach for PCR-mediated concatenation of KRAS and EGFR exons: Rapid way to detect EGFR and KRAS mutations. F1000Research 4: 160 

30      Mittra I, Khare NK, Raghuram GV, Chaubal R, Khambatti F, Gupta D, Gaikwad A, Prasannan P, Singh A, Iyer A, Singh A, Upadhyay P, Nair NK, Mishra PK, Dutt A (2015) Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes. Journal of Biosciences 40: 91-111

29      Chandrani P, Upadhyay P, Iyer P, Tanna M, Shetty M, Raghuram GV, Oak N, Singh A, Chaubal R, Ramteke M, Gupta S, Dutt A (2015) Integrated genomics approach to identify biologically relevant alterations in fewer samples. BMC Genomics 16: 936

28      Chandrani P, Kulkarni V, Iyer P, Upadhyay P, Chaubal R, Das P, Mulherkar R, Singh R, Dutt A (2015) NGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome. British Journal of Cancer 112: 1958-1965

27      Barreto SG, Barreto M, Chaubal R, Dutt A (2015) The fight against cancer: Is it worthwhile? Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology 36: 85-86


26      Choughule A, Sharma R, Trivedi V, Thavamani A, Noronha V, Joshi A, Desai S, Chandrani P, Sundaram P, Utture S, Jambhekar N, Gupta S, Aich J, Prabhash K, Dutt A (2014) Coexistence of KRAS mutation with mutant but not wild-type EGFR predicts response to tyrosine-kinase inhibitors in human lung cancer. British Journal of Cancer 111: 2203-2204

25      Barreto SG, Dutt A, Chaudhary A (2014) A genetic model for gallbladder carcinogenesis and its dissemination. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 25: 1086-1097

24      Upadhyay P, Dwivedi R, Dutt A (2014) Application of NGS in Cancer Research. Current Science, 2014; 107 (5), 795


23      Noronha V, Prabhash K, Thavamani A, Chougule A, Purandare N, Joshi A, Sharma R, Desai S, Jambekar N, Dutt A, Mulherkar R (2013) EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy. PloS one 8: e61561

22      Chougule A, Prabhash K, Noronha V, Joshi A, Thavamani A, Chandrani P, Upadhyay P, Utture S, Desai S, Jambhekar N, Dutt A (2013) Frequency of EGFR mutations in 907 lung adenocarcioma patients of Indian ethnicity. PloS one 8: e76164

21      Choughule A, Noronha V, Joshi A, Desai S, Jambhekar N, Utture S, Thavamanni A, Prabhash K, Dutt A (2013) Epidermal growth factor receptor mutation subtypes and geographical distribution among Indian non-small cell lung cancer patients. Indian journal of cancer 50: 107-111


20      Hammerman PS, Sos ML, Ramos AH, Xu C, Dutt A, Zhou W, Brace LE, Woods BA, Lin W, Zhang J, Deng X, Lim SM, Heynck S, Peifer M, Simard JR, Lawrence MS, Onofrio RC, Salvesen HB, Seidel D, Zander T, Heuckmann JM, Soltermann A, Moch H, Koker M, Leenders F, Gabler F, Querings S, Ansen S, Brambilla E, Brambilla C, Lorimier P, Brustugun OT, Helland A, Petersen I, Clement JH, Groen H, Timens W, Sietsma H, Stoelben E, Wolf J, Beer DG, Tsao MS, Hanna M, Hatton C, Eck MJ, Janne PA, Johnson BE, Winckler W, Greulich H, Bass AJ, Cho J, Rauh D, Gray NS, Wong KK, Haura EB, Thomas RK, Meyerson M (2011) Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer discovery 1: 78-89

19      Dutt A, Ramos AH, Hammerman PS, Mermel C, Cho J, Sharifnia T, Chande A, Tanaka KE, Stransky N, Greulich H, Gray NS, Meyerson M (2011) Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PloS one 6: e20351

18      Cho J, Pastorino S, Zeng Q, Xu X, Johnson W, Vandenberg S, Verhaak R, Cherniack AD, Watanabe H, Dutt A, Kwon J, Chao YS, Onofrio RC, Chiang D, Yuza Y, Kesari S, Meyerson M (2011) Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies. Cancer research 71: 7587-7596


17      Zhou W, Hur W, McDermott U, Dutt A, Xian W, Ficarro SB, Zhang J, Sharma SV, Brugge J, Meyerson M, Settleman J, Gray NS (2010) A structure-guided approach to creating covalent FGFR inhibitors. Chemistry & biology 17: 285-295


16      Salvesen HB, Carter SL, Mannelqvist M, Dutt A, Getz G, Stefansson IM, Raeder MB, Sos ML, Engelsen IB, Trovik J, Wik E, Greulich H, Bo TH, Jonassen I, Thomas RK, Zander T, Garraway LA, Oyan AM, Sellers WR, Kalland KH, Meyerson M, Akslen LA, Beroukhim R (2009) Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. Proceedings of the National Academy of Sciences of the United States of America 106: 4834-4839

15      Ramos AH, Dutt A, Mermel C, Perner S, Cho J, Lafargue CJ, Johnson LA, Stiedl AC, Tanaka KE, Bass AJ, Barretina J, Weir BA, Beroukhim R, Thomas RK, Minna JD, Chirieac LR, Lindeman NI, Giordano T, Beer DG, Wagner P, Wistuba, II, Rubin MA, Meyerson M (2009) Amplification of chromosomal segment 4q12 in non-small cell lung cancer. Cancer biology & therapy 8: 2042-2050

14      Dutt A, Salvesen HB, Greulich H, Sellers WR, Beroukhim R, Meyerson M (2009) Somatic mutations are present in all members of the AKT family in endometrial carcinoma. British journal of cancer 101: 1218-1219; author reply 1220-1211

13      Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M (2009) SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature genetics 41: 1238-1242


12      Dutt A, Salvesen HB, Chen TH, Ramos AH, Onofrio RC, Hatton C, Nicoletti R, Winckler W, Grewal R, Hanna M, Wyhs N, Ziaugra L, Richter DJ, Trovik J, Engelsen IB, Stefansson IM, Fennell T, Cibulskis K, Zody MC, Akslen LA, Gabriel S, Wong KK, Sellers WR, Meyerson M, Greulich H (2008) Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proceedings of the National Academy of Sciences of the United States of America 105: 8713-8717

11      Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba, II, Ozenberger B, Good PJ, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK (2008) Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455: 1069-1075


10      Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, MacConaill L, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery C, Greulich H, Shah K, Sasaki H, Gazdar A, Minna J, Armstrong SA, Mellinghoff IK, Hodi FS, Dranoff G, Mischel PS, Cloughesy TF, Nelson SF, Liau LM, Mertz K, Rubin MA, Moch H, Loda M, Catalona W, Fletcher J, Signoretti S, Kaye F, Anderson KC, Demetri GD, Dummer R, Wagner S, Herlyn M, Sellers WR, Meyerson M, Garraway LA (2007) High-throughput oncogene mutation profiling in human cancer. Nature genetics 39: 347-351

9        Dutt A, Beroukhim R (2007) Single nucleotide polymorphism array analysis of cancer. Current opinion in oncology 19: 43-49


8        Murtaza I, Mushtaq D, Margoob MA, Dutt A, Wani NA, Ahmad I, Bhat ML (2006) A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley. World journal of gastroenterology 12: 4033-4037

7        Murtaza I, Marra G, Schlapbach R, Patrignani A, Kunzli M, Wagner U, Sabates J, Dutt A (2006) A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray. Biotechnology and applied biochemistry 45: 29-36

6        Dutt A, Wong KK (2006) Mouse models of lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 12: 4396s-4402s


5        Murtaza I, Dutt A, Mushtaq D, Ali A (2005) Molecular cloning and genetic analysis of functional merB gene from indian isolates of Escherichia coli. Current microbiology 51: 297-302


4        Dutt A, Canevascini S, Froehli-Hoier E, Hajnal A (2004) EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid. PLoS biology 2: e334


3        Murtaza ID, A.; Ali, A. (2002) Biomolecular engineering of organomercurial lyase in Escherichia coli. Indian J Biotech 1: 117-120

2        Murtaza I, Dutt A, Ali A (2002) Relationship between the persistence of mer operon sequences in Escherichia coli and their resistance to mercury. Current microbiology 44: 178-183


1        Murtaza ID, A.; Ali, A. (2001) Inducible mercury operons in Broad Spectrum Escherichia coli. Indian J Microbiology 41

Meeting Reports

3          Chow LWC, Luis C, Teh B, Li D, Feng G, Guan X, Nair A, Zhu L, Sugimoto M, Dutt A, Toi M, Gupta S, Badwe R, Knapp S, Pillai MR, Kumar R (2016) Cancer Genomics and Biology 2015 Genes & Cancer

2          Kumar RH, Toi M, Sato F, Pillai MR, Costa L, Carmo-Fonseca M, Knapp S, Dutt A, Gupta S, Badwe R (2013) The Global Cancer Genomics Consortium’s Second Annual Symposium: Genomics Medicine in Cancer Research Genes & Cancer 4: 196-200

1          Global Cancer Genomics C (2012) The Global Cancer Genomics Consortium: interfacing genomics and cancer medicine. Cancer research 72: 3720-3724