Publications and Presentations

 

Research articles:

 

1. Kar M, Khan NA, Panwar A, Bais SS, Basak S, Goel R, Sopory S, Medigeshi GR. Zinc Chelation Specifically Inhibits Early Stages of Dengue Virus Replication by Activation of NF-κB and Induction of Antiviral Response in Epithelial Cells. Frontiers in Immunology. 2019;10(2347). doi: 10.3389/fimmu.2019.02347.
2. Bais SS, Ratra Y, Khan NA, Pandey R, Kushawaha PK, Tomar S, Medigeshi G, Singh A, Basak S. Chandipura virus utilizes the pro-survival function of RelA NF-kappaB for its propagation. Journal of virology. 2019. Epub 2019/05/03. doi: 10.1128/JVI.00081-19. PubMed PMID: 31043529.
3. Kumar R, Singh N, Abdin MZ, Patel AH, Medigeshi GR. Dengue Virus Capsid Interacts with DDX3X–A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection. Frontiers in Cellular and Infection Microbiology. 2018;7(542). doi: 10.3389/fcimb.2017.00542.
4. Kar M, Nisheetha A, Kumar A, Jagtap S, Shinde J, Singla M, M S, Pandit A, Chandele A, Kabra SK, Krishna S, Roy R, Lodha R, Pattabiraman C, Medigeshi GR. Isolation and molecular characterization of Dengue virus clinical isolates from pediatric patients in New Delhi. Int J Infect Dis. 2018. Epub 2018/12/12. doi: 10.1016/j.ijid.2018.12.003. PubMed PMID: 30528666.
5. Ojha A, Nandi D, Batra H, Singhal R, Annarapu GK, Bhattacharyya S, Seth T, Dar L, Medigeshi GR, Vrati S, Vikram NK, Guchhait P. Platelet activation determines the severity of thrombocytopenia in dengue infection. Scientific reports. 2017;7:41697. doi: 10.1038/srep41697. PubMed PMID: 28139770; PMCID: PMC5282509.
6. Kumar P, Medigeshi GR, Mishra VS, Islam M, Randev S, Mukherjee A, Chaudhry R, Kapil A, Ram Jat K, Lodha R, Kabra SK. Etiology of Acute Respiratory Infections in Infants: A Prospective Birth Cohort Study. Pediatr Infect Dis J. 2017;36(1):25-30. Epub 2016/10/19. doi: 10.1097/INF.0000000000001359. PubMed PMID: 27753796.
7. Kar M, Singla M, Chandele A, Kabra SK, Lodha R, Medigeshi GR. Dengue Virus Entry and Replication Does Not Lead to Productive Infection in Platelets. Open Forum Infect Dis. 2017;4(2):ofx051. doi: 10.1093/ofid/ofx051. PubMed PMID: 28491890; PMCID: PMC5420081.
8. Jain N, Oswal N, Chawla AS, Agrawal T, Biswas M, Vrati S, Rath S, George A, Bal V, Medigeshi GR. CD8 T cells protect adult naive mice from JEV-induced morbidity via lytic function. PLoS neglected tropical diseases. 2017;11(2):e0005329. Epub 2017/02/06. doi: 10.1371/journal.pntd.0005329. PubMed PMID: 28151989; PMCID: PMC5308832.
9. Bosch I, de Puig H, Hiley M, Carre-Camps M, Perdomo-Celis F, Narvaez CF, Salgado DM, Senthoor D, O'Grady M, Phillips E, Durbin A, Fandos D, Miyazaki H, Yen CW, Gelvez-Ramirez M, Warke RV, Ribeiro LS, Teixeira MM, Almeida RP, Munoz-Medina JE, Ludert JE, Nogueira ML, Colombo TE, Terzian ACB, Bozza PT, Calheiros AS, Vieira YR, Barbosa-Lima G, Vizzoni A, Cerbino-Neto J, Bozza FA, Souza TML, Trugilho MRO, de Filippis AMB, de Sequeira PC, Marques ETA, Magalhaes T, Diaz FJ, Restrepo BN, Marin K, Mattar S, Olson D, Asturias EJ, Lucera M, Singla M, Medigeshi GR, de Bosch N, Tam J, Gomez-Marquez J, Clavet C, Villar L, Hamad-Schifferli K, Gehrke L. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum. Sci Transl Med. 2017;9(409). doi: 10.1126/scitranslmed.aan1589. PubMed PMID: 28954927.
10. Singla M, Kar M, Sethi T, Kabra SK, Lodha R, Chandele A, Medigeshi GR. Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India--Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity. PLoS neglected tropical diseases. 2016;10(3):e0004497. Epub 2016/03/18. doi: 10.1371/journal.pntd.0004497. PubMed PMID: 26982706; PMCID: PMC4794248.
11. Medigeshi GR, Kumar R, Dhamija E, Agrawal T, Kar M. N-Desmethylclozapine, Fluoxetine, and Salmeterol Inhibit Postentry Stages of the Dengue Virus Life Cycle. Antimicrob Agents Chemother. 2016;60(11):6709-18. Epub 2016/08/31. doi: 10.1128/AAC.01367-16. PubMed PMID: 27572397; PMCID: PMC5075077.
12. Kumar R, Agrawal T, Khan NA, Nakayama Y, Medigeshi GR. Identification and characterization of the role of c-terminal Src kinase in dengue virus replication. Scientific reports. 2016;6:30490. Epub 2016/07/28. doi: 10.1038/srep30490. PubMed PMID: 27457684; PMCID: PMC4960526.
13. Kakumani PK, Medigeshi GR, Kaur I, Malhotra P, Mukherjee SK, Bhatnagar RK. Role of human GRP75 in miRNA mediated regulation of dengue virus replication. Gene. 2016;586(1):7-11. Epub 2016/04/04. doi: 10.1016/j.gene.2016.03.053. PubMed PMID: 27039024.
14. Jenum S, Dhanasekaran S, Lodha R, Mukherjee A, Kumar Saini D, Singh S, Singh V, Medigeshi G, Haks MC, Ottenhoff TH, Doherty TM, Kabra SK, Ritz C, Grewal HM. Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum. Scientific reports. 2016;6:18520. Epub 2016/01/05. doi: 10.1038/srep18520. PubMed PMID: 26725873; PMCID: PMC4698754.
15. Chandele A, Sewatanon J, Gunisetty S, Singla M, Onlamoon N, Akondy RS, Kissick HT, Nayak K, Reddy ES, Kalam H, Kumar D, Verma A, Panda H, Wang S, Angkasekwinai N, Pattanapanyasat K, Chokephaibulkit K, Medigeshi GR, Lodha R, Kabra S, Ahmed R, Murali-Krishna K. Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India. Journal of virology. 2016;90(24):11259-78. Epub 2016/11/01. doi: 10.1128/JVI.01424-16. PubMed PMID: 27707928; PMCID: PMC5126381.
16. Kakumani PK, Rajgokul KS, Ponia SS, Kaur I, Mahanty S, Medigeshi GR, Banerjea AC, Chopra AP, Malhotra P, Mukherjee SK, Bhatnagar RK. Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner. The Biochemical journal. 2015;471(1):89-99. doi: 10.1042/BJ20150445. PubMed PMID: 26221025.
17. Kakumani PK, Ponia SS, S RK, Sood V, Chinnappan M, Banerjea AC, Medigeshi GR, Malhotra P, Mukherjee SK, Bhatnagar RK. Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor. Journal of virology. 2013;87(16):8870-83. Epub 2013/06/07. doi: 10.1128/JVI.02774-12. PubMed PMID: 23741001; PMCID: PMC3754049.
18. Haridas V, Rajgokul KS, Sadanandan S, Agrawal T, Sharvani V, Gopalakrishna MV, Bijesh MB, Kumawat KL, Basu A, Medigeshi GR. Bispidine-amino acid conjugates act as a novel scaffold for the design of antivirals that block Japanese encephalitis virus replication. PLoS neglected tropical diseases. 2013;7(1):e2005. Epub 2013/01/26. doi: 10.1371/journal.pntd.0002005. PubMed PMID: 23350007; PMCID: PMC3547849.
19. Agrawal T, Sharvani V, Nair D, Medigeshi GR. Japanese encephalitis virus disrupts cell-cell junctions and affects the epithelial permeability barrier functions. PloS one. 2013;8(7):e69465. Epub 2013/07/31. doi: 10.1371/journal.pone.0069465. PubMed PMID: 23894488; PMCID: PMC3722119.
20. Agrawal T, Schu P, Medigeshi GR. Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle. Scientific reports. 2013;3:1813. Epub 2013/05/10. doi: 10.1038/srep01813. PubMed PMID: 23657274; PMCID: PMC3648799.
21. Wertheimer AM, Uhrlaub JL, Hirsch A, Medigeshi G, Sprague J, Legasse A, Wilk J, Wiley CA, Didier P, Tesh RB, Murray KO, Axthelm MK, Wong SW, Nikolich-Zugich J. Immune response to the West Nile virus in aged non-human primates. PloS one. 2010;5(12):e15514. doi: 10.1371/journal.pone.0015514. PubMed PMID: 21151986; PMCID: PMC2996299.
22. Medigeshi GR, Hirsch AJ, Brien JD, Uhrlaub JL, Mason PW, Wiley C, Nikolich-Zugich J, Nelson JA. West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function. Journal of virology. 2009;83(12):6125-34. Epub 2009/04/17. doi: 10.1128/JVI.02617-08. PubMed PMID: 19369347; PMCID: PMC2687390.
23. Goodman AG, Fornek JL, Medigeshi GR, Perrone LA, Peng X, Dyer MD, Proll SC, Knoblaugh SE, Carter VS, Korth MJ, Nelson JA, Tumpey TM, Katze MG. P58(IPK): a novel "CIHD" member of the host innate defense response against pathogenic virus infection. PLoS pathogens. 2009;5(5):e1000438. Epub 2009/05/23. doi: 10.1371/journal.ppat.1000438. PubMed PMID: 19461876; PMCID: PMC2677460.
24. Medigeshi GR, Krikunova M, Radhakrishnan K, Wenzel D, Klingauf J, Schu P. AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin. Traffic. 2008;9(1):121-32. Epub 2007/11/09. doi: 10.1111/j.1600-0854.2007.00672.x. PubMed PMID: 17988225.
25. Medigeshi GR, Hirsch AJ, Streblow DN, Nikolich-Zugich J, Nelson JA. West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin. Journal of virology. 2008;82(11):5212-9. Epub 2008/04/04. doi: 10.1128/JVI.00008-08. PubMed PMID: 18385233; PMCID: PMC2395215.
26. Medigeshi GR, Lancaster AM, Hirsch AJ, Briese T, Lipkin WI, Defilippis V, Fruh K, Mason PW, Nikolich-Zugich J, Nelson JA. West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis. Journal of virology. 2007;81(20):10849-60. Epub 2007/08/10. doi: 10.1128/JVI.01151-07. PubMed PMID: 17686866; PMCID: PMC2045561.
27. Scott GK, Fei H, Thomas L, Medigeshi GR, Thomas G. A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. The EMBO journal. 2006;25(19):4423-35. Epub 2006/09/16. doi: 10.1038/sj.emboj.7601336. PubMed PMID: 16977309; PMCID: PMC1589982.
28. Hirsch AJ, Medigeshi GR, Meyers HL, DeFilippis V, Fruh K, Briese T, Lipkin WI, Nelson JA. The Src family kinase c-Yes is required for maturation of West Nile virus particles. Journal of virology. 2005;79(18):11943-51. Epub 2005/09/06. doi: 10.1128/JVI.79.18.11943-11951.2005. PubMed PMID: 16140770; PMCID: PMC1212629.
29. Medigeshi GR, Schu P. Characterization of the in vitro retrograde transport of MPR46. Traffic. 2003;4(11):802-11. Epub 2003/11/18. PubMed PMID: 14617361.
30. Roy N, Guruprasad MR, Kondaiah P, Mann EA, Giannella RA, Visweswariah SS. Protein kinase C regulates transcription of the human guanylate cyclase C gene. European journal of biochemistry / FEBS. 2001;268(7):2160-71. PubMed PMID: 11277940.
31. Meyer C, Eskelinen EL, Guruprasad MR, von Figura K, Schu P. Mu 1A deficiency induces a profound increase in MPR300/IGF-II receptor internalization rate. Journal of cell science. 2001;114(Pt 24):4469-76. PubMed PMID: 11792812.
32. Vijayachandra K, Guruprasad M, Bhandari R, Manjunath UH, Somesh BP, Srinivasan N, Suguna K, Visweswariah SS. Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer. Biochemistry. 2000;39(51):16075-83. Epub 2000/12/22. PubMed PMID: 11123935.

 

Review

 

1. Medigeshi GR. Mosquito-borne flaviviruses: overview of viral life-cycle and host–virus interactions. Future Virology. 2011;6(9):1075-89. doi: 10.2217/fvl.11.85.

 

Perspective:

 

1. Medigeshi GR, Fink K, Hegde NR. Position Paper on Road Map for RNA Virus Research in India. Frontiers in Microbiology. 2018;9(1753). doi: 10.3389/fmicb.2018.01753.

 

 

 

Book Chapter:

 

1. Charles Grose, L. M., Guruprasad R. Medigeshi, Gregory K. Scott, and Gary Thomas. 2006. Endocytosis of Varicella Zoster Virus Glycoproteins: Virion Envelopment and Egress. Horizon Scientific Press.