Publications and Presentations

1. Telford N, Alexander S, McGinn OJ, Williams M, Wood KM, Bloor A, Saha V. Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6-LYN gene fusion. Blood Cancer J. 2016;6:e412.
2. Schwab C, Ryan SL, Chilton L, Elliott A, Murray J, Richardson S, Wragg C, Moppett J, Cummins M, Tunstall O, Parker CA, Saha V, Goulden N, Vora A, Moorman AV, Harrison CJ. EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): genetic profile and clinical implications. Blood. 2016 May 5;127(18):2214-8.
3. Johnson SM, Dempsey C, Chadwick A, Harrison S, Liu J, Di Y, McGinn OJ, Fiorillo M, Sotgia F, Lisanti MP, Parihar M, Krishnan S, Saha V. Metabolic reprogramming of bone marrow stromal cells by leukemic extracellular vesicles in acute lymphoblastic leukemia. Blood. 2016 Jul 21;128(3):453-6.
4. Irving JA, Enshaei A, Parker CA, Sutton R, Kuiper RP, Erhorn A, Minto L, Venn NC, Law T, Yu J, Schwab C, Davies R, Matheson E, Davies A, Sonneveld E, den Boer ML, Love SB, Harrison CJ, Hoogerbrugge PM, Revesz T, Saha V, Moorman AV. Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukaemia. Blood. 2016 May 26.
5. Cuvertino S, Filiciotto G, Masurekar A, Saha V, Lacaud G, Kouskoff V. SOX7 promotes the maintenance and proliferation of B cell precursor acute lymphoblastic cells. Oncotarget. 2016 Jul 7.
6. Vassal G, Rousseau R, Blanc P, Moreno L, Bode G, Schwoch S, Schrappe M, Skolnik J, Bergman L, Bradley-Garelik MB, Saha V, Pearson A, Zwierzina H. Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer. Eur J Cancer. 2015 Jan;51(2):218-24.
7. Liu J, Masurekar A, Johnson S, Chakraborty S, Griffiths J, Smith D, Alexander S, Dempsey C, Parker C, Harrison S, Li Y, Miller C, Di Y, Ghosh Z, Krishnan S, Saha V. Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia. Oncotarget. 2015 Dec 15;6(40):43048-64.
8. van der Veer A, Zaliova M, Mottadelli F, De Lorenzo P, Te Kronnie G, Harrison CJ, Cave H, Trka J, Saha V, Schrappe M, Pieters R, Biondi A, Valsecchi MG, Stanulla M, den Boer ML, Cazzaniga G. IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL. Blood. 2014 Mar 13;123(11):1691-8.
9. Stevens A, Hanson D, de Leonibus C, Whatmore A, Donn R, White DJ, Liu J, van den Heuvel-Eibrink MM, Saha V, Clayton PE, Meyer S. EVI1 expression in childhood acute lymphoblastic leukaemia is not restricted to MLL and BCR/ABL rearrangements and is influenced by age. Blood Cancer J. 2014;4:e179.
10. Masurekar AN, Parker CA, Shanyinde M, Moorman AV, Hancock JP, Sutton R, Ancliff PJ, Morgan M, Goulden NJ, Fraser C, Hoogerbrugge PM, Revesz T, Darbyshire PJ, Krishnan S, Love SB, Saha V. Outcome of central nervous system relapses in childhood acute lymphoblastic leukaemia--prospective open cohort analyses of the ALLR3 trial. PLoS One. 2014;9(10):e108107.
11. Masurekar A, Fong C, Hussein A, Revesz T, Hoogerbrugge PM, Love S, Ciria C, Parker C, Krishnan S, Saha V. The optimal use of PEG-asparaginase in relapsed ALL--lessons from the ALLR3 Clinical Trial. Blood Cancer J. 2014;4:e203.
12. Bhattacharyya A, Krishnan S, Saha V, Goel G, Bhattacharya S, Hmar L. Microbiology, infection control and infection related outcome in pediatric patients in an oncology center in Eastern India: Experience from Tata Medical Center, Kolkata. Indian J Cancer. 2014 Oct-Dec;51(4):415-7.
13. Chowdhury K, Saha S, Saha VP, Pal S, Chatterjee I. Pre and post operative voice analysis after medialization thyroplasty in cases of unilateral vocal fold paralysis. Indian J Otolaryngol Head Neck Surg. 2013 Dec;65(4):354-7.
14. Chen DW, Saha V, Liu JZ, Schwartz JM, Krstic-Demonacos M. Erg and AP-1 as determinants of glucocorticoid response in acute lymphoblastic leukemia. Oncogene. 2013 Jun 20;32(25):3039-48.
15. Schrappe M, Hunger SP, Pui CH, Saha V, Gaynon PS, Baruchel A, Conter V, Otten J, Ohara A, Versluys AB, Escherich G, Heyman M, Silverman LB, Horibe K, Mann G, Camitta BM, Harbott J, Riehm H, Richards S, Devidas M, Zimmermann M. Outcomes after induction failure in childhood acute lymphoblastic leukemia. N Engl J Med. 2012 Apr 12;366(15):1371-81.
16. Castro FV, McGinn OJ, Krishnan S, Marinov G, Li J, Rutkowski AJ, Elkord E, Burt DJ, Holland M, Vaghjiani R, Gallego A, Saha V, Stern PL. 5T4 oncofetal antigen is expressed in high risk of relapse childhood pre-B acute lymphoblastic leukemia and is associated with a more invasive and chemotactic phenotype. Leukemia. 2012 Jul;26(7):1487-98.
17. Biondi A, Schrappe M, De Lorenzo P, Castor A, Lucchini G, Gandemer V, Pieters R, Stary J, Escherich G, Campbell M, Li CK, Vora A, Arico M, Rottgers S, Saha V, Valsecchi MG. Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study. Lancet Oncol. 2012 Sep;13(9):936-45.
18. van Delft FW, Horsley S, Colman S, Anderson K, Bateman C, Kempski H, Zuna J, Eckert C, Saha V, Kearney L, Ford A, Greaves M. Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia. Blood. 2011 Jun 9;117(23):6247-54.
19. Offman MN, Krol M, Patel N, Krishnan S, Liu J, Saha V, Bates PA. Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity. Blood. 2011 Feb 3;117(5):1614-21.
20. Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, Bitton D, Mulryan K, Ashton G, Blaylock M, Bagley S, Connolly Y, Bridgeman J, Miller C, Krishnan S, Dempsey C, Masurekar A, Stern P, Whetton A, Saha V. RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia. Blood. 2011 Jul 21;118(3):638-49.
21. Saha V, Shanson E, Shankar A, Samuel D, Millar M. Hospital ventilation, heat and humidity: risk of fungal and other infections. J Hosp Infect. 2010 May;75(1):74-5.
22. Parker C, Waters R, Leighton C, Hancock J, Sutton R, Moorman AV, Ancliff P, Morgan M, Masurekar A, Goulden N, Green N, Revesz T, Darbyshire P, Love S, Saha V. Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial. Lancet. 2010 Dec 11;376(9757):2009-17.
23. Krishnan S, Wade R, Moorman AV, Mitchell C, Kinsey SE, Eden TO, Parker C, Vora A, Richards S, Saha V. Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001. Leukemia. 2010 Feb;24(2):450-9.
24. Arico M, Schrappe M, Hunger SP, Carroll WL, Conter V, Galimberti S, Manabe A, Saha V, Baruchel A, Vettenranta K, Horibe K, Benoit Y, Pieters R, Escherich G, Silverman LB, Pui CH, Valsecchi MG. Clinical outcome of children with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia treated between 1995 and 2005. J Clin Oncol. 2010 Nov 1;28(31):4755-61.
25. Patel N, Krishnan S, Offman MN, Krol M, Moss CX, Leighton C, van Delft FW, Holland M, Liu J, Alexander S, Dempsey C, Ariffin H, Essink M, Eden TO, Watts C, Bates PA, Saha V. A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase. J Clin Invest. 2009 Jul;119(7):1964-73.
26. Strefford JC, Worley H, Barber K, Wright S, Stewart AR, Robinson HM, Bettney G, van Delft FW, Atherton MG, Davies T, Griffiths M, Hing S, Ross FM, Talley P, Saha V, Moorman AV, Harrison CJ. Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization. Oncogene. 2007 Jun 21;26(29):4306-18.
27. Saha V. Simplifying treatment for children with ALL. Lancet. 2007 Jan 13;369(9556):82-3.
28. Strefford JC, van Delft FW, Robinson HM, Worley H, Yiannikouris O, Selzer R, Richmond T, Hann I, Bellotti T, Raghavan M, Young BD, Saha V, Harrison CJ. Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8167-72.
29. Walls T, Hawrami K, Ushiro-Lumb I, Shingadia D, Saha V, Shankar AG. Adenovirus infection after pediatric bone marrow transplantation: is treatment always necessary? Clin Infect Dis. 2005 May 1;40(9):1244-9.
30. van Delft FW, Bellotti T, Luo Z, Jones LK, Patel N, Yiannikouris O, Hill AS, Hubank M, Kempski H, Fletcher D, Chaplin T, Foot N, Young BD, Hann IM, Gammerman A, Saha V. Prospective gene expression analysis accurately subtypes acute leukaemia in children and establishes a commonality between hyperdiploidy and t(12;21) in acute lymphoblastic leukaemia. Br J Haematol. 2005 Jul;130(1):26-35.
31. Roy A, Cargill A, Love S, Moorman AV, Stoneham S, Lim A, Darbyshire PJ, Lancaster D, Hann I, Eden T, Saha V. Outcome after first relapse in childhood acute lymphoblastic leukaemia - lessons from the United Kingdom R2 trial. Br J Haematol. 2005 Jul;130(1):67-75.
32. Roy A, Bradburn M, Moorman AV, Burrett J, Love S, Kinsey SE, Mitchell C, Vora A, Eden T, Lilleyman JS, Hann I, Saha V, Medical Research Council Childhood Leukaemia Working P. Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: results of the Medical Research Council ALL 97 trial. Br J Haematol. 2005 Apr;129(1):35-44.
33. Jones LK, Saha V. Philadelphia positive acute lymphoblastic leukaemia of childhood. Br J Haematol. 2005 Aug;130(4):489-500.
34. Bury J, Hurt C, Roy A, Cheesman L, Bradburn M, Cross S, Fox J, Saha V. LISA: a web-based decision-support system for trial management of childhood acute lymphoblastic leukaemia. Br J Haematol. 2005 Jun;129(6):746-54.
35. Bellotti T, Luo Z, Gammerman A, Van Delft FW, Saha V. Qualified predictions for microarray and proteomics pattern diagnostics with confidence machines. Int J Neural Syst. 2005 Aug;15(4):247-58.
36. Zuna J, Ford AM, Peham M, Patel N, Saha V, Eckert C, Kochling J, Panzer-Grumayer R, Trka J, Greaves M. TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia. Clin Cancer Res. 2004 Aug 15;10(16):5355-60.
37. van Delft FW, Saha V. Molecular techniques to improve outcome in childhood ALL. Methods Mol Med. 2004;91:111-22.
38. Bury J, Hurt C, Roy A, Bradburn M, Cross S, Fox J, Saha V. A quantitative and qualitative evaluation of LISA, a decision support system for chemotherapy dosing in childhood acute lymphoblastic leukaemia. Stud Health Technol Inform. 2004;107(Pt 1):197-201.
39. Stoneham S, Lennard L, Coen P, Lilleyman J, Saha V. Veno-occlusive disease in patients receiving thiopurines during maintenance therapy for childhood acute lymphoblastic leukaemia. Br J Haematol. 2003 Oct;123(1):100-2.
40. Patel N, Goff LK, Clark T, Ford AM, Foot N, Lillington D, Hing S, Pritchard-Jones K, Jones LK, Saha V. Expression profile of wild-type ETV6 in childhood acute leukaemia. Br J Haematol. 2003 Jul;122(1):94-8.
41. Jones LK, Neat MJ, van Delft FW, Mitchell MP, Adamaki M, Stoneham SJ, Patel N, Saha V. Cryptic rearrangement involving MLL and AF10 occurring in utero. Leukemia. 2003 Aug;17(8):1667-9.
42. Gandhi M, Rao K, Chua S, Saha V, Lilleyman J, Shankar A. Routine blood counts in children with acute lymphoblastic leukaemia after completion of therapy: are they necessary? Br J Haematol. 2003 Aug;122(3):451-3.
43. Saha V. Making paediatric oncological research relevant. Hosp Med. 2002 Jan;63(1):54.
44. Lowdell MW, Craston R, Samuel D, Wood ME, O'Neill E, Saha V, Prentice HG. Evidence that continued remission in patients treated for acute leukaemia is dependent upon autologous natural killer cells. Br J Haematol. 2002 Jun;117(4):821-7.
45. Jones LK, Saha V. Chromatin modification, leukaemia and implications for therapy. Br J Haematol. 2002 Sep;118(3):714-27.
46. Jones LK, Chaplin T, Shankar A, Neat M, Patel N, Samuel DP, Hill AS, Debernardi S, Bassini A, Young BD, Saha V. Identification and molecular characterisation of a CALM-AF10 fusion in acute megakaryoblastic leukaemia. Leukemia. 2001 Jun;15(6):910-4.
47. Rao K, Saha V. Medical management of Aspergillus flavus endocarditis. Pediatr Hematol Oncol. 2000 Jul-Aug;17(5):425-7.
48. Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V. Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation. J Mol Biol. 2000 Jun 2;299(2):369-78.
49. Lillington DM, Jaju RJ, Shankar AG, Neat M, Kearney L, Young BD, Saha V. Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia. Br J Haematol. 2000 Sep;110(3):547-51.
50. Wiemels JL, Cazzaniga G, Daniotti M, Eden OB, Addison GM, Masera G, Saha V, Biondi A, Greaves MF. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet. 1999 Oct 30;354(9189):1499-503.
51. Tomlinson RJ, Ronghe M, Goodbourne C, Price C, Lilleyman JS, Das S, Saha V. Once daily ceftriaxone and gentamicin for the treatment of febrile neutropenia. Arch Dis Child. 1999 Feb;80(2):125-31.
52. McCullagh P, Chaplin T, Meerabux J, Grenzelias D, Lillington D, Poulsom R, Gregorini A, Saha V, Young BD. The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene. Oncogene. 1999 Dec 9;18(52):7442-52.
53. Jaju RJ, Haas OA, Neat M, Harbott J, Saha V, Boultwood J, Brown JM, Pirc-Danoewinata H, Krings BW, Muller U, Morris SW, Wainscoat JS, Kearney L. A new recurrent translocation, t(5;11)(q35;p15.5), associated with del(5q) in childhood acute myeloid leukemia. The UK Cancer Cytogenetics Group (UKCCG). Blood. 1999 Jul 15;94(2):773-80.
54. Saha V, Young BD, Freemont PS. Translocations, fusion genes, and acute leukemia. J Cell Biochem Suppl. 1998;30-31:264-76.
55. Linder B, Jones LK, Chaplin T, Mohd-Sarip A, Heinlein UA, Young BD, Saha V. Expression pattern and cellular distribution of the murine homologue of AF10. Biochim Biophys Acta. 1998 Dec 22;1443(3):285-96.
56. Attard-Montalto SP, Hadley J, Kingston JE, Eden OB, Saha V. Ongoing assessment of nutritional status in children with malignant disease. Pediatr Hematol Oncol. 1998 Sep-Oct;15(5):393-403.
57. Goddard AG, Saha V. Late-onset hemorrhagic cystitis following bone marrow transplantation: a case report. Pediatr Hematol Oncol. 1997 May-Jun;14(3):273-5.
58. Young BD, Saha V. Chromosome abnormalities in leukaemia: the 11q23 paradigm. Cancer Surv. 1996;28:225-45.
59. Lucas H, Attard-Montalto SP, Saha V, Bristow A, Kingston JE, Eden OB. Central venous catheter tip position and malfunction in a paediatric oncology unit. Pediatr Surg Int. 1996 Mar;11(2-3):159-63.
60. Gregorini A, Sahin FI, Lillington DM, Meerabux J, Saha V, McCullagh P, Bocci M, Menevse S, Papa S, Young BD. Gene BR140, which is related to AF10 and AF17, maps to chromosome band 3p25. Genes Chromosomes Cancer. 1996 Dec;17(4):269-72.
61. Eden OB, Saha V. Lag time for children with brain tumours. Arch Dis Child. 1996 Sep;75(3):266.
62. Attard-Montalto SP, Saha V, Kingston J, Plowman N, Taylor M, Arlett C, Bridges B, Eden O. Increased radiosensitivity in a child with T-cell non-Hodgkin's lymphoma. Med Pediatr Oncol. 1996 Dec;27(6):564-70.
63. Schuller I, Saha V, Lin L, Kingston J, Eden T, Tabaqchali S. Investigation and management of Clostridium difficile colonisation in a paediatric oncology unit. Arch Dis Child. 1995 Mar;72(3):219-22.
64. Saha V, Lillington DM, Shelling AN, Chaplin T, Yaspo ML, Ganesan TS, Young BD. AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer. Genes Chromosomes Cancer. 1995 Nov;14(3):220-2.
65. Saha V, Eden OB, Hann I, Attard-Montalto S, Cotterill S, Carter R. Primary extra-thoracic T-cell non-Hodgkin's lymphoma of childhood. The United Kingdom Children's Cancer Study Group. Leukemia. 1995 Jan;9(1):40-3.
66. Saha V, Chaplin T, Gregorini A, Ayton P, Young BD. The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9737-41.
67. Kanabar DJ, Attard-Montalto S, Saha V, Kingston JE, Malpas JE, Eden OB. Quality of life in survivors of childhood cancer after megatherapy with autologous bone marrow rescue. Pediatr Hematol Oncol. 1995 Jan-Feb;12(1):29-36.
68. Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD. The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Blood. 1995 Sep 15;86(6):2073-6.
69. Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Blood. 1995 Mar 15;85(6):1435-41.
70. Attard-Montalto SP, Saha V, Ng YY, Kingston JE, Eden OB. High incidence of hypertension in children presenting with acute lymphoblastic leukemia. Pediatr Hematol Oncol. 1994 Sep-Oct;11(5):519-25.
71. Saha V, Stansfield R, Masterton R, Eden T. The treatment of Pseudomonas aeruginosa meningitis--old regime or newer drugs? Scand J Infect Dis. 1993;25(1):81-3.
72. Saha V, Ravikumar E, Khanduri U, Date A, Ponnaiya J, Raghupathy P. Long-term prednisolone therapy in children with idiopathic pulmonary hemosiderosis. Pediatr Hematol Oncol. 1993 Jan-Mar;10(1):89-91.
73. Saha V, Love S, Eden T, Micallef-Eynaud P, MacKinlay G. Determinants of symptom interval in childhood cancer. Arch Dis Child. 1993 Jun;68(6):771-4.
74. Saha V, Eden T, Stiller CA, Brown RJ, Mackinlay G. An audit of the activities of the paediatric oncology unit in Edinburgh, 1982-1991. Scott Med J. 1993 Jun;38(3):74-6.
75. Saha V, Eden T. An odyssey in search of a cure: the evolution of treatment of childhood acute lymphoblastic leukemia in the United Kingdom. Indian J Pediatr. 1993 Jul-Aug;60(4):525-38.
76. Attard-Montalto SP, Saha V, Norton AJ, Kingston JE, Eden OB. Anaplastic large cell lymphoma in childhood. Med Pediatr Oncol. 1993;21(9):665-9; discussion 9-70.
77. Attard-Montalto S, Plowman N, Breatnach F, Saha V, Eden OB. Is there a danger in delaying radiotherapy in childhood medulloblastoma? Br J Radiol. 1993 Sep;66(789):807-13.
78. Saha V, Gupta S, Daum RS. Occurrence and mechanisms of glycopeptide resistance in gram-positive cocci. Infect Agents Dis. 1992 Dec;1(6):310-8.
79. Dutta MK, Saha V, Sarkar P. Detection of rabies virus in different tissues of experimentally infected mice at preclinical and postclinical stages of the disease. Indian J Exp Biol. 1992 Oct;30(10):877-80.
80. Saha V, John TJ, Mukundan P, Gnanamuthu C, Prabhakar S, Arjundas G, Sayeed ZA, Kumaresan G, Srinivas K. High incidence of subacute sclerosing panencephalitis in south India. Epidemiol Infect. 1990 Feb;104(1):151-6.
81. Saha V, John TJ, Dhamodaran S, Carman RH. Highly sensitive screening tests for hepatitis B surface antigen in transfusion centres of developing countries. BMJ. 1988 Jul 30;297(6644):334-5.
82. Andrew R, Hariharan S, Saha V, John JT, Kirubakaran MG, Shastry JC. Biochemical evaluation of ultrafiltrate in dialysis-dependent HBsAG-positive patients. Nephron. 1988;49(1):88.