Publications and Presentations

1.       S Ganesan, A A Alex, E Chendamarai, N Balasundaram, H K Palani, S David, U Kulkarni, M Aiyaz, R Mugasimangalam, A Korula, A Abraham, A Srivastava, R A Padua, C Chomienne, B George, P Balasubramanian, V Mathews. Rationale and efficacy of proteasome inhibitor combined with arsenic trioxide in the treatment of acute promyelocytic leukemia. Leukemia. accepted article preview 18 August 2016; doi: 10.1038/leu.2016.227.

2.       Deshpande PA, Srivastava VM, Mani S, Anandhan S, Meena J, Abraham A, Viswabandya A, George B, Srivastava A, Mathews V, Balasubramanian P. Atypical BCR-ABL1 fusion transcripts in adult B-acute lymphoblastic leukemia, including a novel fusion transcript-e8a1. Leuk Lymphoma. 2016 Mar 4:1-4. [Epub ahead of print] No abstract available. PMID: 26942999.

3.       Philip C, George B, Korula A, Srivastava A, Balasubramanian P, Mathews V. Treatment rates of paediatric acute myeloid leukaemia: a view from three tertiary centres in India - response to Gupta et al. Br J Haematol. 2015 Dec 2. doi: 10.1111/bjh.13857. [Epub ahead of print] No abstract available. PMID: 26627639.

4.       Abraham A, Varatharajan S, Karathedath S, Philip C, Lakshmi KM, Jayavelu AK, Mohanan E, Janet NB, Srivastava VM, Shaji RV, Zhang W, Abraham A, Viswabandya A, George B, Chandy M, Srivastava A, Mathews V, Balasubramanian P. RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia. Pharmacogenomics. 2015 Jul;16(8):877-90. doi: 10.2217/pgs.15.44. Epub 2015 Jun 17. PMID: 26083014.

5.       Philip C, George B, Ganapule A, Korula A, Jain P, Alex AA, Lakshmi KM, Sitaram U, Abubacker FN, Abraham A, Viswabandya A, Srivastava VM, Srivastava A, Balasubramanian P, Mathews V. Acute myeloid leukaemia: challenges and real world data from India. Br J Haematol. 2015 Jul;170(1):110-7. doi: 10.1111/bjh.13406. Epub 2015 Apr 9. PMID: 25858293.

6.       Chendamarai E, Ganesan S, Alex AA, Kamath V, Nair SC, Nellickal AJ, Janet NB, Srivastava V, Lakshmi KM, Viswabandya A, Abraham A, Aiyaz M, Mullapudi N, Mugasimangalam R, Padua RA, Chomienne C, Chandy M, Srivastava A, George B, Balasubramanian P, Mathews V. Comparison of newly diagnosed and relapsed patients with acute promyelocytic leukemia treated with arsenic trioxide: insight into mechanisms of resistance. PLoS One. 2015 Mar 30;10(3):e0121912. doi: 10.1371/journal.pone.0121912. eCollection 2015. PMID: 25822503.

7.       Arora N, Nair S, Pai R, Nair S, Ahmed R, Abraham A, Viswabandya A, George B, Balasubramanian P, Srivastava A, Mathews V. V-raf murine sarcoma viral oncogene homolog B (BRAF) mutations in hairy cell leukaemia. Indian J Pathol Microbiol. 2015 Jan-Mar;58(1):62-5. doi: 10.4103/0377-4929.151190. PMID: 25673595.

8.       Abraham A, Devasia AJ, Varatharajan S, Karathedath S, Balasubramanian P, Mathews V. Effect of cytosine arabinoside metabolizing enzyme expression on drug toxicity in acute myeloid leukemia.Ann Hematol. 2014 Nov 13. [Epub ahead of print] PMID: 25391240.

9.       Abraham A, Karathedath S, Kumaraswamy V, Jayavelu AK, M S, Srivastava VM, Zhang W, Zhou T, George B, Srivastava A, Mathews V, Balasubramanian P*. Novel NPM1 mutation in the 3'-untranslated region identified in two patients with acute myeloid leukemia. Leuk Lymphoma.2014 Jun;55(6):1421-4.

10.   Abraham A, Karathedath S, Varatharajan S, Markose P, Chendamarai E, Jayavelu AK, George B, Srivastava A, Mathews V, Balasubramanian P*. ABCB6 RNA expression in Leukemias-expression is low in acute promyelocytic leukemia and FLT3-ITD-positive acute myeloid leukemia. Ann Hematol. 2014 Mar;93(3):509-12.

11.   Rajagopal V, Sundaresan L, Rajkumar AP, Chittybabu C, Kuruvilla A, Srivastava A, Balasubramanian P, Jacob KS, Jacob M. Genetic association between the DRD4 promoter polymorphism and clozapine-induced sialorrhea. Psychiatr Genet. 2014 Dec;24(6):273-6.

12.   Agarwala MK, George R, Mathews V, Balasubramanian P, Thomas M, Nair S. Role of imatinib in the treatment of pediatric onset indolent systemic mastocytosis: a case report. J Dermatolog Treat. 2013 Dec; 24 (6):481-3.

13.   A.P. Rajkumar, B. Poonkuzhali, A. Kuruvilla A. Srivastava M. Jacob K.S. Jacob. Outcome definitions and clinical predictors influence associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia. Psychopharmacology (Berl). 2012 Dec; 224 (3):441-9.

14.   A.P. Rajkumar, B. Poonkuzhali, A. Kuruvilla A. M. Jacob and K.S. Jacob. Clinical predictors of serum clozapine levels in patients with Treatment Resistant Schizophrenia. International Clinical Psychopharmacology 2013 Jan; 28(1):50.

15.   Ezhilarasi Chendamarai, Poonkuzhali Balasubramanian, Biju George, Auro Viswabandya, Aby Abraham, Rayaz Ahmed, Ansu Abu Alex, Saravanan Ganesan, Kavitha M Lakshmi, Usha Sitaram, Sukesh Chandran Nair, Mammen Chandy, Nancy Beryl Janet, Vivi M. Srivastava, Alok Srivastava, Vikram Mathews. Role of Minimal Residual Disease Monitoring in Acute Promyelocytic Leukemia Treated with Arsenic Trioxide in Frontline Therapy. Blood 2012 Apr 12; 119(15):3413-9.

16.   Salamun Desire, Ezhilpavai Mohanan, Biju George, Vikram Mathews, Alok Srivastava, Mammen Chandy and Poonkuzhali Balasubramanian*. A rapid and sensitive liquid chromatography- tandem mass spectrometry method for the quantitation of busulfan levels in plasma- application for routine therapeutic monitoring in hematopoietic stem cell transplantation. Indian J Med Res. 2013 Apr; 137(4):777-84.

17.   Savitha Varatharajan, Ajay Abraham, Salar Abbas, Wei Zhang, Shaji R.V, Rayaz Ahmed, Aby Abraham, Biju George, Alok Srivastava, Mammen Chandy, Vikram Mathews and Poonkuzhali Balasubramanian*. Carbonyl reductase-1 RNA expression influences in-vitro daunorubicin cytotoxicity and intracellular daunorubicinol levels in AML cells. Eur J Clin Pharmacol, 2012 Dec; 68(12):1577-86.

18.   Ajay Abraham, Savitha Varatharajan, Salar Abbas, Wei Zhang, Shaji R.V, Rayaz Ahmed, Aby Abraham, Biju George, Alok Srivastava, Mammen Chandy, Vikram Mathews and Poonkuzhali Balasubramanian*. Pharmacogenetics of Cytidine Deaminase in Acute myeloid leukemia blasts and normal lymphocytes. Pharmacogenomics, 2012 Feb; 13(3):269-82.

19.   Balasubramanian P*, Chendamarai E, Markose P, Fletcher L, Branford S, George B, Mathews V, Chandy M, Srivastava A. International Reporting Scale of BCR-ABL1 Fusion Transcript in Chronic Myeloid Leukemia: First Report from India. Acta Haematol. 2012 Jan 2; 127(3):135-142.

20.   Balasubramanian P*, Desire S, Panetta JC, Lakshmi KM, Mathews V, George B, Viswabandya A, Chandy M, Krishnamoorthy R, Srivastava A. Population pharmacokinetics of cyclophosphamide in patients with thalassemia major undergoing HSCT. Bone Marrow Transplant. 2012 Jan 9. doi: 10.1038/bmt.2011.254.

21.   A.P. Rajkumar, B. Poonkuzhali, A. Kuruvilla A. Srivastava M. Jacob K.S. Jacob. Association between CYP1A2 gene single nucleotide polymorphisms and clinical responses to clozapine in patients with treatment-resistant schizophrenia. Acta Neuropsychiatrica, Volume 25 / Issue 01 / February 2013, pp 2-11.

22.   A.P. Rajkumar, B. Poonkuzhali, A. Kuruvilla, K.S. Jacob. Clinical predictors of response to clozapine in patients with Treatment Resistant Schizophrenia. Psychopharmacology Bulletin, Volume 44; Number 3: 2011.

23.   Bugalia A, Abraham A, Balasubramanian P, Srivastava A, Nair S. Mast cell sarcoma of the small intestine: a case report. J Clin Pathol. 2011 Nov; 64(11):1035-7.

24.   Parihar M, Mathews, Alok Srivastava, Mammen Chandy. Frequency of TPMT alleles in Indian patients with Acute Lymphatic leukemia and effect on the dose of 6-mercaptopurine. Med Oncol 2010 Dec; 27(4):1046-9.

25.   Monika Gupta, Ashok Kumar J, Usha Sitaram, S Neeraj, A Nancy, Poonkuzhali Balasubramanian, Aby Abraham, Vikram Mathews, Auro Viswabandya, Biju George, Mammen Chandy, Alok Srivastava, Vivi M Srivastava. The t(6;9)(p22;q34) in myeloid neoplasia: A retrospective study of 16 cases. Cancer Genet Cytogenet. 2010 Dec; 203(2):297-302.

26.   Mathews V, George B, Chendamarai E, Lakshmi KM, Desire S, Balasubramanian P, Viswabandya P, Thirugnanam R, Abraham A, Shaji RV, Srivastava A, Chandy M. Single Agent Arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: Long Term Follow Up Data. J Clin Oncol. 2010 Aug 20; 28(24):3866-71.

27.   Salamun Desire, Poonkuzhali Balasubramanian*, Ashish Bajel, Biju George, Auro Viswabandya, Vikram Mathews, Alok Srivastava, Mammen Chandy. Frequency of TPMT alleles in Indian patients with Acute Lymphatic leukemia and effect on the dose of 6-mercaptopurine. Med Oncol 2010 Dec; 27(4):1046-9.

28.   Markose P, Chendamarai E, Poonkuzhali B*, Shaji R.V, Vivi M Srivastava, Vikram Mathews, Biju George, Auro Viswabandya, Alok Srivastava and Mammen Chandy. Spectrum of Bcr-Abl kinase domain mutations in patients with chronic myeloid leukemia from India with suspected resistance to imatinib- mutations are rare and have different distributions. Leukemia Lymphoma 2009 Dec; 50(12):2092-5.

29.   Deeken JF, Robey RW, Shukla S, Steadman K, Chakraborty A, Poonkuzhali B, Schuetz EG, Holbeck S, Ambudkar SV, Bates SE. Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen. Mol Pharmacol. 2009 Nov; 76(5):946-56.

30.   Thirugnanam R, George B, Chendamarai E, Lakshmi KM, Balasubramanian P, Viswabandya A, Srivastava A, Chandy M, Mathews V. Comparison of clinical outcomes of patients with relapsed acute promyelocytic leukemia induced with arsenic trioxide and consolidated with either an autologous stem cell transplant or an arsenic trioxide-based regimen. Biol Blood Marrow Transplant. 2009 Nov; 15(11):1479-84.

31.   Charles M. Rudin, Wanqing Liu, Apurva Desai, Theodore Karrison, Xuemin Jiang, Linda Janisch, Soma Das, Jacqueline Ramirez, Balasubramanian Poonkuzhali, Erin Schuetz, Donna Lee Fackenthal, Peixian Chen, Deborah K. Armstrong, Julie R. Brahmer, Gini F. Fleming, Everett E. Vokes, Michael A. Carducci, Mark J. Ratain. Pharmacogenomic and pharmacokinetic  determinants of erlotinib toxicity. J Clin Oncol 2008; Mar 1; 26(7):1119-27.

32.   Partha Krishnamurthy, Matthias Schwab, Kazumasa Takenaka, Deepa Nachagari, Jessica Morgan, Mark Leslie, Weinan Du, Kelli Boyd, Meyling Cheok, Hiromitsu Nakauchi, Richard Kim, Balasubramanian Poonkuzhali, Erin Schuetz, William Evans, Mary Relling and John Schuetz. Transporter-Mediated Protection against Thiopurine-Induced Hematologic Toxicity. Cancer Res 2008; 68(13):4983-9.

33.   Balasubramanian Poonkuzhali, Jatinder Lamba, Stephen Strom, Alex Sparreboom, Kenneth Thummel, Paul Watkins, and Erin Schuetz. Association of BCRP/ABCG2 Phenotypes with Novel promoter and intron1 SNPs. Drug Metab Dispos. 2008 Apr; 36(4):780-95.

34.   Marzolini C, Tirona RG, Gervasini G, Poonkuzhali B, Assem M, Lee W, Leake BF, Schuetz JD, Schuetz EG, Kim RB. A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression. Mol Endocrinol. 2007 Aug; 21(8):1769-80.

35.   Mathews V, George B, Lakshmi KM, Viswabandya A, Bajel A, Balasubramanian P, Shaji RV, Srivastava VM, Srivastava A, Chandy M. Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity. Blood 2006 Apr 1; 107(7):2627-32.

36.    Sellathamby S, Balasubramanian Poonkuzhali, Sivalingam S, Shaji RV, Mathews V, George B, Viswabandya A, Srivastava A, Chandy M. Developing an algorithm of informative markers for evaluation of chimerism after allogeneic bone marrow transplantation. Bone Marrow Transplant 2006 Apr; 37(8):751-5.

37.   Chandy M, Balasubramanian P, Ramachandran SV, Mathews V, George B, Dennison D, Krishnamoorthy R, Srivastava A. Randomized trial of two different conditioning regimens for bone marrow transplantation in thalassemia--the role of busulfan pharmacokinetics in determining outcome. Bone Marrow Transplant 2005 Nov;

38.   Poonkuzhali B*, Shaji RV, Salamun DE, George B, Srivastava A, Chandy M. Cytochrome P4501A1 and glutathione S transferase gene polymorphisms in patients with aplastic anemia in India. Acta Haematol 2005; 114(3):127-32.

39.   George B, Poonkuzhali B, Srivastava VM, Chandy M, Srivastava A. Hematological and molecular remission with combination chemotherapy in a patient with PLZF-RAR alpha acute promyelocytic leukemia (APML). Ann Hematol. 2005 Jun; 84(6):406-8.

40.   Srivastava A, Poonkuzhali B, Shaji RV, George B, Mathews V, Chandy M, Krishnamoorthy R. Glutathione Stransferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood 2004 Sep 1; 104(5):1574-7.

41.   George B, Mathews L, Balasubramanian P, Shaji RV, Srivastava A, Chandy M. Molecular remission with arsenic trioxide in patients with newly diagnosed acute promyelocytic leukemia. Haematologica 2004 Oct; 89(10):1266-7.

42.   George B, Mathews V, Poonkuzhali B, Shaji RV, Srivastava A, Chandy M. Treatment of children with newly diagnosed acute promyelocytic leukemia with arsenic trioxide: a single center experience. Leukemia 2004 Oct; 18(10):1587-90.

43.   Shaji RV, Edison ES, Poonkuzhali B, Srivastava A, Chandy M. Rapid detection of beta-globin gene mutations and polymorphisms by temporal temperature gradient gel electrophoresis. Clin Chem. 2003 May; 49(5):777-81.

44.   Mathews V, Balasubramanian P, Shaji RV, George B, Chandy M, Srivastava A. Arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: a single center experience. Am J Hematol 2002 Aug; 70(4):292-9.

45.    Shivakumar S, Poonkhuzhali B, Gunasekaran S, Srivastava A, Chandy M. Cytogenetic, fluorescent in situ hybridization & reverse transcriptase-polymerase chain reaction analysis in acute promyelocytic leukaemia patients. Indian J Med Res. 2002 Feb; 115:59-67.

46.   Balasubramanian P, Chandy M, Krishnamoorthy R, Srivastava A. Evaluation of existing limited sampling models for busulfan kinetics in children with beta thalassaemia major undergoing bone marrow transplantation. Bone Marrow Transplant 2001 Nov; 28(9):821-5.

47.   Mathews V, Balasubramanian P, Shaji RV, George B, Chandy M, Srivastava A. Central nervous system relapse in a patient with acute promyelocytic leukaemia treated with arsenic tri-oxide. Br J Haematol 2001 Apr; 113(1):

48.   Balasubramanian P*, Srivastava A, Chandy M. Stability of busulfan in frozen plasma and whole blood samples. Clin Chem. 2001 Apr; 47(4):766-8.

49.    Poonkuzhali B, Chandy M, Srivastava A, Dennison D, Krishnamoorthy R. Glutathione S-transferase activity influences busulfan pharmacokinetics in patients with beta thalassemia major undergoing bone marrow transplantation. Drug Metab Dispos 2001 Mar; 29(3):264-7.

50.   Poonkuzhali B, Srivastava A, Quernin MH, Dennison D, Aigrain EJ, Kanagasabapathy AS, Krishnamoorthy R, Chandy M. Pharmacokinetics of oral busulphan in children with beta thalassaemia major undergoing allogeneic bone marrow transplantation. Bone Marrow Transplant 1999 Jul; 24(1):5-11.

51.   Quernin MH, Poonkuzhali B, Médard Y, Dennison D, Srivastava A, Krishnamoorthy R, Chandy M, Jacqz- Aigrain E. High-performance liquid chromatographic method for quantification of busulfan in plasma after derivatization by tetrafluorothiophenol. J Chromatogr B Biomed Sci Appl. 1999 Jan 8; 721(1):147-52.

52.   Quernin MH, Poonkuzhali B, Montes C, Krishnamoorthy R, Dennison D, Srivastava A, Vilmer E, Chandy M, Jacqz-Aigrain E. Quantification of busulfan in plasma by gas chromatography-mass spectrometry following derivatization with tetrafluorothiophenol. J Chromatogr B Biomed Sci Appl. 1998 May 8; 709(1):47-56.

53.   Poonkuzhali B, Victoria J, Selvakumar R, Dennison D, Srivastava A, Jeyaseelan L, Chandy M, Kanagasabapathy AS. Comparison of HPLC & EMIT methods of cyclosporine assay in blood after bone marrow transplantation. Indian J Med Res. 1995 Jul; 102:39-41.

54.   Poonkuzhali B, Saraswathi CP, Rajalakshmi K. Effect of uric acid on sodium oxalate-induced urolithiasis in rats—biochemical and histological evidences. Indian J Exp Biol. 1994 Jan; 32(1):20-4.