Publications and Presentations


SINCE JOINING IISER (August 2016 - present) (work supported by funding from the India Alliance)


24. Chattopadhyay, T., Maniyadath, B., Bagul, H. P., Chakraborty, A., Shukla, N., Budnar, S., Rajendran, A., Shukla, A., Kamat, S. S., Kolthur-Seetharam, U. (2020) Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic swithcing and prevents hyderglycemia, PNAS (accepted, In Press).

23. Rajendran, A.*, Vaidya, K., Mendoza, J., Bridwell-Rabb, J., Kamat, S. S.* (2020) Functional characterization of ABHD14B, an orphan serine serine hydrolase enzyme, Biochemistry 59 (2), 183-196. (*co-corresponding authors) (Article featured in the "Future of Biochemistry: Asia Pacific" edition in January 2020). 

22. Kumar, M., Ojha,S., Rai, P., Joshi, A., Kamat, S. S., Mallik, R. M. (2019) Insulin activates intracellular transport of lipid droplets to release triglycerides from the liver, Journal of Cell Biology 218 (11), 3697-3713. 

21. Kulkarni, A., Soni, I., Kelkar, D. S., Sankar, R. K., Beniwal, G., Rajendran, A., Tamhankar, S., Chopra, S.*, Kamat, S. S.*, Chakrapani, H*. (2019) Chemoproteomics of an indole-based quinone-epoxide identifies druggable vulnerabilities in vancomycin resistant Staphylococcus aureus, Journal of Medicinal Chemistry 62 (14), 6785-6795. (*co-corresponding authors)

20. Malik, S. A., Achraya, J., Mehendale, N., Kamat, S. S., Ghaskadbi, S. (2019) Pterostilbene reverses palmitic acid mediated insulin resistance in HepG2 cells by reducing oxidative stress and triglyceride accumulation, Free Radical Research 53 (7), 815-827.

19. Kelkar, D. S., Ravikumar, G., Mehendale, N., Singh, S., Joshi, A., Sharma, A. K., Mhetre, A., Rajendran, A., Chakrapani, H., Kamat, S. S.* (2019) A chemical genetic screen identifies ABHD12 as an oxidized phosphatidylserine lipase, Nature Chemical Biology 15, 169-178. (*corresponding author)[Youtube video on this paper]

18. Chaplot, K., Pimpale, L., Ramalingam, B., Deivasigamani, S., Kamat, S. S., Ratnaparkhi, G. S. (2019) SOD1 activity thresholds and TOR signaling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a Drosophila model of Amylotrophic Lateral Sclerosis, Disease Models & Mechanisms 12(2), dmm033803, 1-15. (This article featured on the cover of the February 2019 issue).

17. Joshi, A., Shaikh, M., Singh, S., Rajndran, A., Mhetre, A., Kamat, S. S.* (2018) Biochemical characterization of the PHARC associated serine hydrolase ABHD12 reveals its preference for very long chain lipids, Journal of Biological Chemistry 293 (44), 16953-16963. (This article featured on the cover of the 2nd November 2018 issue). (*corresponding author)

16. Abhyankar, V., Kaduskar, B., Kamat, S. S., Deobagkar, D., Ratnaparkhi, G. S. (2018) Drosophila DNA/RNA methyltransferase contributes to robust host defense in ageing animals by regulating sphingolipid metabolism, Journal of Experimental Biology 221 (22), 1-10

15. Pathak, D., Mehendale, N., Singh, S., Mallik, R., Kamat, S. S.* (2018) Lipidomics suggests a new role for ceramide synthase in phagocytosis, ACS Chemical Biology 13 (8), 2280-2287. (This article featured on the cover of the August 2018 issue). (*corresponding author)

14. Rai, P., Kumar, M., Sharma, G., Barak, P., Das, S., Kamat, S. S., Mallik, R. M. (2017) Kinesin-dependent mechanism for controlling triglyceride secretion from the liver, PNAS 114 (49), 12958-12963.


From Postdoc (The Scripps Research Institute) (January 2013 - July 2016)

13. Kory, N., Grond, S., Kamat, S. S., Li, Z., Krahmer, N., Chitraju, C., Zhou, P., Fronlich, F., Semova, I., Ejsing, C., Zechner, R., Cravatt, B. F., Farese, R. V., Walther, T. C. (2017) Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism, J. Lipid Research 58, 226-235.

12. Kolar, M. J., Kamat, S. S., Parsons, W. H., Homan, E., Maher, T., Peroni, O., Syed, I., Molven, A., Kahn, B. B., Cravatt, B. F., Saghatelian, A. (2016) Branched fatty acid esters of hydroxyl fatty acids are preferred substrates of the MODY8 gene carboxyl ester lipase, Biochemistry 55, 4636-4641.

11. Ogura, Y., Parsons, W. H., Kamat, S. S., Cravatt, B. F. (2016) A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines. Nature Chemical Biology 12, 669-671.

10. Parsons, W. H., Kolar, M. J., Kamat, S. S., Cognetta, A. B. III, Hulce, J. J., Saez, E., Kahn, B., Saghatelian, A. S., Cravatt, B. F. (2016) AIG1 and ADTRP are atypical membrane hydrolase that degrade bioactive FAHFAs, Nature Chemical Biology 12, 367-372.

9. Kamat, S. S., Camara, K., Parsons, W. H., Chen, D. H., Dix, M. M., Bird, T. D., Howell, A. R., Cravatt, B. F. (2015) Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay, Nature Chemical Biology 11,164-171.

8. Camara, K., Kamat, S. S., Lasota, C. C., Cravatt, B. F., Howell, A. R. (2015) Combining cross-metathesis and activity based protein profiling: new β-lactone motifs for targeting serine hydrolases, Bio. Org. Med. Chem. Let. 25, 317-321.


From Ph.D. (Texas A&M University) (August 2007 - December 2012)

7. Korczynska, M., Xiang, D. F., Zhang, Z., Xu, C., Narindoshvili, T., Kamat, S. S., Williams, H. J., Chang, S. S., Kolb, P., Hillerich, B. S., Sauder, J. M., Burley, S. K., Almo, S. C., Swaminathan, S., Shoichet, B. K., Raushel, F. M. (2014) Functional annotation and structural characterization of a novel lactonase D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate, Biochemistry 53, 4727-4738.

6. Kamat, S. S., Burgos, E. S., Raushel, F. M. (2013) Potent inhibition of the C-P lyase nucleosidase PhnI by immucillinA-triphosphate, Biochemistry 52, 7366-7368.

5. Kamat, S. S., Williams, H. J., Dangott L. J., Chakrabarti, M., Raushel, F. M. (2013) The catalytic mechanism for the aerobic formation of methane by bacteria, Nature 497, 132-36. 

4. Kamat, S. S., Williams, H. J., Raushel, F. M. (2011) Intermediates in the transformation of phosphonates to phosphate by bacteria, Nature 480, 570-73. 

3. Kamat, S. S., Holmes-Hampton, G. P., Bagaria, A., Kumran, D., Tichy, S. E., Gheyi, T., Zheng, X., Bain, K., Groshong, C., Emtage, S., Sauder, J. M., Burley, S. K., Swaminathan, S., Lindahl, P. A., Raushel, F. M. (2011) The catalase activity of diiron adenine deaminase, Protein Science 20, 2080-94.

2. Kamat, S. S., Fan, H., Sauder, J. M., Burley, S. K., Shoichet, B. K., Sali, A., Raushel, F. M. (2011): Enzymatic deamination of the epigenetic base N-6-methyladenine, JACS 133, 2080-83. 

1. Kamat, S. S., Bagaria, A., Kumaran, D., Holmes-Hampton, G. P., Fan, H., Sali, A., Sauder, J. M., Burley, S. K., Lindahl, P. A., Swaminathan, S., Raushel, F. M. (2011): Catalytic mechanism and three dimensional structure of adenine deaminase, Biochemistry 50, 1917-27. 



SINCE JOINING IISER (August 2016 - present)

6. Kamat, S. S.*, Singh, S., Rajendran, A., Gama, S., Zechel, D. L.* (2019) Enzymatic strategies for the catabolism of organophosphonates, Comprehensive Natural Products III: Enzymes and Enzyme Mechanisms, Book 4. (* co-corresponding authors) (Accepted, In Press).

5. Ulrich, E., Kamat, S. S.*, Hove-Jensen, B.*, Zechel, D. L.* (2018) Chapter 13: Methylphosphonic acid biosynthesis and catabolism in pelagic bacteria, Methods in Enzymology Vol. 605, 351-426 (* co-corresponding authors)


From Ph.D. (Texas A&M University) (August 2007 - December 2012)

4. Kamat, S. S., Raushel, F. M. (2015) PhnJ – A novel radical SAM enzyme from the C-P lyase complex, Perspectives in Science 4, 32-37.

3. Kamat, S. S., Raushel, F. M. (2013) Adenine Deaminase, Encyclopedia of Inorganic and Bioinorganic Chemistry, 1-9.

2. Kamat, S. S., Raushel F. M. (2013) The enzymatic conversion of phosphonates to phosphate by bacteria, Current Opinions in Chemical Biology 17, 589-596.

1. Kamat, S. S., Williams, H. J., Raushel, F. M. (2013) Phosphonates to phosphate: A functional annotation of the essential genes of the phn operon in Escherichia coli, Beilstein Institut Proceedings, 5th International Symposium on Experimental Standard Conditions of Enzyme Characterizations (ESCEC), 1-18



1. Kamat, S. S. (2019) Understanding the role of molecular motors in living cells: an odyssey from physics to biology. Current Science 116, 14-16.