Publications and Presentations

Chinnaswamy S, Yarbrough I, Palaninathan S, Kumar CT, Vijayaraghavan V, Demeler B, Lemon SM, Sacchettini JC and  Kao CC  (2008) A locking mechanism regulates RNA synthesis and host protein interaction by the Hepatitis C Virus RNA polymerase,  Journal of Biological Chemistry, 283(29):20535-46.

McGivern DR, Villanueva RA, Chinnaswamy S, Kao CC and Lemon SM. (2009) Impaired replication of Hepatitis C Virus containing mutations in a conserved NS5B retinoblastoma protein-binding motif. Journal Of Virology. 83(15): 7422-33.

Liu Z, Robida JM, Chinnaswamy S, Yi G, Robotham JM, Nelson HB, Irsigler A, Kao CC and  Tang H  (2009) Mutations in the Hepatitis C virus polymerase that increase RNA binding can confer resistance to Cyclosporine A. Hepatology  50(1): 25-33.

Chinnaswamy S, Ayaluru M, Fujisaki K, Li P and Kao CC. (2010)  Regulation of de novo initiated RNA synthesis in the hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions, Journal Of Virology, 84(12):5923-35.

Chinnaswamy S*, Ayaluru M*,  Yi G, Cai H, Palaninathan S and Kao CC (2010) Conformations of the monomeric hepatitis C virus RNA-dependent RNA polymerase. Virus Adaptation And Treatment, 2:21-39. (* equal contributions).

Chinnaswamy S, Cai H and Kao CC (2010) An update on the small molecule inhibitors of the HCV NS5B polymerase: effects on RNA synthesis in vitro, on cultured cells and potential resistance in viral quasispecies. Virus Adaptation And Treatment, 2:73-89.

Kao CC, Fan B, Chinnaswamy S, Cai H, Ranjith-Kumar CT and Deval J (2012) Assays for RNA Synthesis and Replication by the Hepatitis C Virus. Frontiers in Biology , 7(3):233-245.

Chinnaswamy S and Lott WB (2012) The adenine-rich tract in the 5’ end of the hepatitis C virus ORF encodes a peptide regulating the binding of the C protein to RNA. Acta Virologica (56: 217 – 226, 2012).

Chinnaswamy S*, Chatterjee S, Boopathi R, Mukherjee S, Bhattacharjee S and Kundu TK (2013) A single nucleotide polymorphism associated with hepatitis C virus infections located in the distal region of the IL28B promoter influences NF-kB –mediated gene transcription. PLoS ONE (8(10): e75495. doi:10.1371/journal.pone.0075495) (*Corresponding author).

Chinnaswamy S (2014) Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights in to host-virus interactions.  J Interferon and Cytokine Research 34(7): 479-497.

Chinnaswamy S*, Das K, Bairagya BB, Bhattacharyya C, Shalimar, Duseja A, Amarapurkar D, Rosangluaia, Chowdhury S, Konar A, Majumder PP, Chowdhury A* (2014) Association of IL28B single nucleotide polymorphism rs8099917 with response to treatment in genotype 3 HCV-infected patients from India. Tropical Gastroenterology 35(2): 96-102. (*Corresponding authors).

Chinnaswamy S*, Bhushan A, Behera AK, Ghosh S, Rampurkar V, Chandra V, Pandit B, Kundu TK (2016) Roles for transcription factors Sp1, NF-kB, IRF3 and IRF7 in expression of the human IFNL4 gene. Viral Immunology 29(1):49-63. (*Corresponding author).

Chinnaswamy S. (2016) Gene-disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections. Genes and Immunity 17: 265-275.

Chinnaswamy S*, Wardzynska A, Pawelczyk M, Makowska J, Skaaby T, Mercader JM, Ahluwalia TS, Grarup N, Guindo-Martinez M, Bisgaard H, Torrents D, Linneberg A, Bonnelykke K, Kowalski ML (2017) A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma. Scientific Reports Sep 5;7(1):10500. doi: 10.1038/s41598-017-10467-y.

Bhushan A, Ghosh S, Battacharjee S, Chinnaswamy S* (2017). Confounding by SNP rs117648444 (P70S) affects the association of IFNL locus variants with response to IFN-RBV therapy in patients with chronic genotype 3 HCV infection. J Interferon and Cytokine Research 37(8): 369-382. (*Corresponding author).

Bhushan A, Chinnaswamy S* (2018) Identifying causal variants at the interferon lambda locus in case-control studies: Utilizing non-synonymous variant rs117648444 to probe the role of IFN-λ4. GENE 664: 168-180.

Chinnaswamy S*, Kowalski ML. (2019). The genetic association of IFN-λs with human inflammatory disorders remains a conundrum.  J Interferon and Cytokine Research. (doi.org/10.1089/jir.2019.0009)