Publications and Presentations

 
  1. Widjaja, WA.; Singh, BK.; Adami, E.; Viswanathan, S.; D'Agostino, GA.; Dong, JR.; Ng, B.; Tan, J.; Paleja, BS.; Tripathi, M.; Lim, SY.; Chothani, S.; Lim, WW.; Rabes, A.; Sombetzki, M.; Bruinstroop,E.; Sinha, RA.; Albani, S.; Yen, PM.; Schafer, S.; Cook, SA. IL-11 neutralising therapies target hepatic stellate cell-induced liver inflammation and fibrosis in NASH. Gastroenterology. 2019 (In Press).
  2. Upadhyay, A.; Anjum, B.; Godbole, NM.; Rajak, S.; Shukla, P.; Tiwari, S.; Sinha, RA# .; Godbole, MM. Time-restricted feeding reduces high-fat diet associated placental inflammation and limits adverse effects on fetal organ development. Biochemical and biophysical research communications 2019. (In Press). #Corresponding Author.
  3. Pal, S., Maurya, Sk.; Chattopadhyay, S.; PalChina , S.; Porwal, K.; Kulkarni, Chirag.; Sanyal, S.; Sinha RA.; Chattopadhyay N. The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts. Biochemical Pharmacology. 2019 (In Press).
  4. Zhou, Jin.; Ng, B.; Ko, N.S.J.; Fiedler, LR.; Khin, E.; Lim, A.;  Sahib, N.E.; Wu, Y.; Bay, B.H.; Sinha, R.A.; Cook, S.A.; Yen, P.M., Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo. Hum Mol Genetics. 2019 (In Press).
  5. Sinha, R.A.; Bruinstroop, E.; Singh, B.K.; Yen, P.M., Non-alcoholic fatty liver disease and hypercholesterolemia: Roles of thyroid hormone, metabolites, and agonists. Thyroid. 2019 (Under Minor Revision). Review article.
  6. Tan, HWS.; Anjum, B.; Han-Ming, S., Ghosh, S.; Yen, P.M.; Sinha, R.A#., Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels. Autophagy 2019, (In Press). #Corresponding Author.
  7. Yau, W. W.; Singh, B. K.; Lesmana, R.; Zhou, J.; Sinha, R. A.; Wong, K. A.; Wu, Y.; Bay, B. H.; Sugii, S.; Sun, L.; Yen, P. M., Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and mTOR-mediated mitophagy. Autophagy 2019, Jan;15(1):131-150.
  8. Singh, B.K.; Sinha, R. A.; Yen, P. M., Novel transcriptional mechanisms for regulating metabolism by thyroid hormone. Int J Mol Sciences 2018, Oct 22;19(10). Review article.
  9. Rastogi, L.; Godbole, M. M.; Sinha, R.A.; Pradhan, S, Reverse triiodothyronine (rT3) attenuates ischemia-reperfusion injury. Biochemical and biophysical research communications 2018, Nov 30;506(3):597-603.
  10. Singh, B. K.; Sinha, R. A.; Tripathi, M.; Mendoza, A.; Ohba, K.; Sy, J. A. C.; Xie, S. Y.; Zhou, J.; Ho, J. P.; Chang, C. Y.; Wu, Y.; Giguere, V.; Bay, B. H.; Vanacker, J. M.; Ghosh, S.; Gauthier, K.; Hollenberg, A. N.; McDonnell, D. P.; Yen, P. M., Thyroid hormone receptor and ERRalpha coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. Sci Signal 2018, Jun 26;11(536).
  11. Zhou, J.; Sinha, R. A*.; Lesmana, R.; Yau, W. W. Y.; Yen, P. M., Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro. Methods Mol Biol 2018, 1801, 111-122. DOI: 10.1007/978-1-4939-7902-8_11.*Co-First Author. Book Chapter.
  12. Sinha, R. A#.; Singh, B. K.; Yen, P. M., Direct effects of thyroid hormones on hepatic lipid metabolism. Nature reviews Endocrinology 2018, 14 (5), 259-269. DOI: 10.1038/nrendo.2018.10. #Corresponding Author. Review article.
  13. Kumar, P.; Godbole, N. M.; Chaturvedi, C. P.; Singh, R. S.; George, N.; Upadhyay, A.; Anjum, B.; Godbole, M. M.; Sinha, R. A#., Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism. Biochemical and biophysical research communications 2018. DOI: 10.1016/j.bbrc.2018.05.173. #Corresponding Author.
  14. Bruinstroop, E.; Dalan, R.; Yang, C.; Bee, Y. M.; Chandran, K.; Cho, L. W.; Soh, S. B.; Teo, E. K.; Toh, S. A.; Leow, M. K. S.; Sinha, R. A.; Sadananthan, S. A.; Michael, N.; Stapleton, H.; Leung, C.; Angus, P. W.; Patel, S. K.; Burrell, L. M.; Chi, L. S.; Fang, S. C.; Velan, S. S.; Yen, P. M., Low Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients with Type 2 Diabetes Mellitus and NAFLD. The Journal of clinical endocrinology and metabolism 2018. DOI: 10.1210/jc.2018-00475.
  15. Zhou, J.; Chong, S. Y.; Lim, A.; Singh, B. K.; Sinha, R. A.; Salmon, A. B.; Yen, P. M., Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. Aging 2017, 9 (2), 583-599. DOI: 10.18632/aging.101181.
  16. Sinha, R. A#.; Singh, B. K.; Zhou, J.; Xie, S.; Farah, B. L.; Lesmana, R.; Ohba, K.; Tripathi, M.; Ghosh, S.; Hollenberg, A. N.; Yen, P. M., Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. Autophagy 2017, 13 (1), 169-186. DOI: 10.1080/15548627.2016.1235123. #Corresponding Author.
  17. Sinha, R. A#.; Singh, B. K.; Yen, P. M., Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis. Endocrine reviews 2017, 38 (1), 69-102. DOI: 10.1210/er.2016-1103. #Corresponding Author. Review article.
  18. Singh, B. K.; Sinha, R. A.; Ohba, K.; Yen, P. M., Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy. Molecular and cellular endocrinology 2017, 458, 160-168. DOI: 10.1016/j.mce.2017.02.018. Review article.
  19. Ohba, K.; Sinha, R. A.; Singh, B. K.; Iannucci, L. F.; Zhou, J.; Kovalik, J. P.; Liao, X. H.; Refetoff, S.; Sng, J. C. G.; Leow, M. K.; Yen, P. M., Changes in Hepatic TRbeta Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model. Thyroid : official journal of the American Thyroid Association 2017, 27 (6), 852-860. DOI: 10.1089/thy.2016.0456.
  20. Iannucci, L. F.; Cioffi, F.; Senese, R.; Goglia, F.; Lanni, A.; Yen, P. M.; Sinha, R. A#., Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet. Scientific reports 2017, 7 (1), 2023. DOI: 10.1038/s41598-017-02205-1. #Corresponding Author.
  21. Farah, B. L.; Sinha, R. A.; Wu, Y.; Singh, B. K.; Lim, A.; Hirayama, M.; Landau, D. J.; Bay, B. H.; Koeberl, D. D.; Yen, P. M., Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa). Scientific reports 2017, 7, 44408. DOI: 10.1038/srep44408.
  22. Farah, B. L.; Landau, D. J.; Wu, Y.; Sinha, R. A.; Loh, A.; Bay, B. H.; Koeberl, D. D.; Yen, P. M., Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia. Molecular genetics and metabolism 2017, 122 (3), 95-98. DOI: 10.1016/j.ymgme.2017.08.013.
  23. Xie, S.; Singh, B.; Yen, P.; Sinha, R#., Activation of Liver X receptors (LXRs) increases sphingolipid biosynthesis in hepatic cells. Matters Select 2016. DOI:10.19185/matters.201611000022. #Corresponding Author.
  24. Tripathi, M.; Zhang, C. W.; Singh, B. K.; Sinha, R. A.; Moe, K. T.; DeSilva, D. A.; Yen, P. M., Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell death & disease 2016, 7 (12), e2513. DOI: 10.1038/cddis.2016.374.
  25. Sinha, R. A#.; Yen, P. M., Mechanisms for Thyroid Hormone Action in the CNS. In Thyroid Hormone Disruption and Neurodevelopment, Koibuchi, N.; Yen, P. M., Eds. Springer New York: New York, NY, 2016; pp 3-21. DOI: 10.1007/978-1-4939-3737-0_1. #Corresponding Author. Book Chapter.
  26. Sinha, R. A.; Yen, P. M., Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD. Cell & bioscience 2016, 6, 46. DOI: 10.1186/s13578-016-0113-7. Review article.
  27. Singh, B. K.; Sinha, R. A.; Zhou, J.; Tripathi, M.; Ohba, K.; Wang, M. E.; Astapova, I.; Ghosh, S.; Hollenberg, A. N.; Gauthier, K.; Yen, P. M., Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. The Journal of biological chemistry 2016, 291 (1), 198-214. DOI: 10.1074/jbc.M115.668673.
  28. Ohba, K.; Leow, M. K.; Singh, B. K.; Sinha, R. A.; Lesmana, R.; Liao, X. H.; Ghosh, S.; Refetoff, S.; Sng, J. C.; Yen, P. M., Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice. Endocrinology 2016, 157 (4), 1660-72. DOI: 10.1210/en.2015-1848.
  29. Lim, A.; Zhou, J.; Sinha, R. A.; Singh, B. K.; Ghosh, S.; Lim, K. H.; Chow, P. K.; Woon, E. C. Y.; Yen, P. M., Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. Biochemical and biophysical research communications 2016, 479 (3), 476-481. DOI: 10.1016/j.bbrc.2016.09.086.
  30. Lesmana, R.; Sinha, R. A.; Singh, B. K.; Zhou, J.; Ohba, K.; Wu, Y.; Yau, W. W.; Bay, B. H.; Yen, P. M., Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. Endocrinology 2016, 157 (1), 23-38. DOI: 10.1210/en.2015-1632.
  31. Iannucci, L. F.; Sun, J.; Singh, B. K.; Zhou, J.; Kaddai, V. A.; Lanni, A.; Yen, P. M.; Sinha, R. A#., Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells. Biochemical and biophysical research communications 2016, 480 (3), 461-467. DOI: 10.1016/j.bbrc.2016.10.072. #Corresponding Author.
  32. Farah, B. L.; Landau, D. J.; Sinha, R. A.; Brooks, E. D.; Wu, Y.; Fung, S. Y. S.; Tanaka, T.; Hirayama, M.; Bay, B. H.; Koeberl, D. D.; Yen, P. M., Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency. Journal of hepatology 2016, 64 (2), 370-379. DOI: 10.1016/j.jhep.2015.10.008.
  33. Zhou, J.; Yong, W. P.; Yap, C. S.; Vijayaraghavan, A.; Sinha, R. A.; Singh, B. K.; Xiu, S.; Manesh, S.; Ngo, A.; Lim, A.; Ang, C.; Xie, C.; Wong, F. Y.; Lin, S. J.; Wan, W. K.; Tan, I. B.; Flotow, H.; Tan, P.; Lim, K. H.; Yen, P. M.; Goh, L. K., An integrative approach identified genes associated with drug response in gastric cancer. Carcinogenesis 2015, 36 (4), 441-51. DOI: 10.1093/carcin/bgv014.
  34. Sinha, R. A#.; Singh, B. K.; Zhou, J.; Wu, Y.; Farah, B. L.; Ohba, K.; Lesmana, R.; Gooding, J.; Bay, B. H.; Yen, P. M., Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. Autophagy 2015, 11 (8), 1341-57. DOI: 10.1080/15548627.2015.1061849. #Corresponding Author.
  35. Kumar, P.; Mohan, V.; Sinha, R. A#.; Chagtoo, M.; Godbole, M. M., Histone deacetylase inhibition reduces hypothyroidism-induced neurodevelopmental defects in rats. The Journal of endocrinology 2015, 227 (2), 83-92. DOI: 10.1530/joe-15-0168. #Corresponding Author.
  36. Zhou, J.; Farah, B. L.; Sinha, R. A.; Wu, Y.; Singh, B. K.; Bay, B. H.; Yang, C. S.; Yen, P. M., Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. PloS one 2014, 9 (1), e87161. DOI: 10.1371/journal.pone.0087161.
  37. Sinha, R. A.; Singh, B. K.; Yen, P. M., Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism. Trends in endocrinology and metabolism: TEM 2014, 25 (10), 538-45. DOI: 10.1016/j.tem.2014.07.001. Review article.
  38. Sinha, R. A.; Farah, B. L.; Singh, B. K.; Siddique, M. M.; Li, Y.; Wu, Y.; Ilkayeva, O. R.; Gooding, J.; Ching, J.; Zhou, J.; Martinez, L.; Xie, S.; Bay, B. H.; Summers, S. A.; Newgard, C. B.; Yen, P. M., Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology (Baltimore, Md.) 2014, 59 (4), 1366-80. DOI: 10.1002/hep.26667. Recommended by F1000, commentries in Hepatology and Nature Reviews Gastroenterology & Hepatology.
  39. Farah, B. L.; Sinha, R. A.; Wu, Y.; Singh, B. K.; Zhou, J.; Bay, B. H.; Yen, P. M., beta-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. PloS one 2014, 9 (6), e98155. DOI: 10.1371/journal.pone.0098155.
  40. Aw, D. K.; Sinha, R. A*.; Xie, S. Y.; Yen, P. M., Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells. Biochemical and biophysical research communications 2014, 447 (4), 569-73. DOI: 10.1016/j.bbrc.2014.04.031. *Co-First Author.
  41. Aw, D. K.; Sinha, R. A*.; Tan, H. C.; Loh, L. M.; Salvatore, D.; Yen, P. M., Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism. The Journal of clinical endocrinology and metabolism 2014, 99 (11), 3965-71. DOI: 10.1210/jc.2013-3408. *Co-First Author.
  42. Sinha, R.; Yen, P. M., Cellular Action of Thyroid Hormone. In Endotext, De Groot, L. J.; Chrousos, G.; Dungan, K.; Feingold, K. R.; Grossman, A.; Hershman, J. M.; Koch, C.; Korbonits, M.; McLachlan, R.; New, M.; Purnell, J.; Rebar, R.; Singer, F.; Vinik, A., Eds. MDText.com, Inc.: South Dartmouth (MA), 2014. Book Chapter.
  43. Yap, C. S.; Sinha, R. A.; Ota, S.; Katsuki, M.; Yen, P. M., Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells. Biochemical and biophysical research communications 2013, 440 (4), 635-9. DOI: 10.1016/j.bbrc.2013.09.116.
  44. Xie, S.; Sinha, R. A*.; Singh, B. K.; Li, G. D.; Han, W.; Yen, P. M., Resveratrol induces insulin gene expression in mouse pancreatic alpha-cells. Cell & bioscience 2013, 3 (1), 47. DOI: 10.1186/2045-3701-3-47. *Co-First Author.
  45. Singh, B. K.; Sinha, R. A.; Zhou, J.; Xie, S. Y.; You, S. H.; Gauthier, K.; Yen, P. M., FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. The Journal of biological chemistry 2013, 288 (42), 30365-72. DOI: 10.1074/jbc.M113.504845.
  46. Pal, A.; Mohan, V.; Modi, D. R.; Sinha, R. A.; Rastogi, L.; Kumar, P.; Godbole, M. M., Iodine plus n-3 fatty acid supplementation augments rescue of postnatal neuronal abnormalities in iodine-deficient rat cerebellum. The British journal of nutrition 2013, 110 (4), 659-70. DOI: 10.1017/s0007114512005569.
  47. Zhou, J.; Chen, G. B.; Tang, Y. C.; Sinha, R. A.; Wu, Y.; Yap, C. S.; Wang, G.; Hu, J.; Xia, X.; Tan, P.; Goh, L. K.; Yen, P. M., Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. BMC medical genomics 2012, 5, 34. DOI: 10.1186/1755-8794-5-34.
  48. Sinha, R. A.; You, S. H.; Zhou, J.; Siddique, M. M.; Bay, B. H.; Zhu, X.; Privalsky, M. L.; Cheng, S. Y.; Stevens, R. D.; Summers, S. A.; Newgard, C. B.; Lazar, M. A.; Yen, P. M., Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. The Journal of clinical investigation 2012, 122 (7), 2428-38. DOI: 10.1172/jci60580.
  49. Mohan, V.; Sinha, R. A.; Pathak, A.; Rastogi, L.; Kumar, P.; Pal, A.; Godbole, M. M., Maternal thyroid hormone deficiency affects the fetal neocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis. Experimental neurology 2012, 237 (2), 477-88. DOI: 10.1016/j.expneurol.2012.07.019.
  50. Pathak, A.; Sinha, R. A.; Mohan, V.; Mitra, K.; Godbole, M. M., Maternal thyroid hormone before the onset of fetal thyroid function regulates reelin and downstream signaling cascade affecting neocortical neuronal migration. Cerebral cortex (New York, N.Y.:1991) 2011, 21 (1), 11-21. DOI: 10.1093/cercor/bhq052.
  51. Babu, S.; Sinha, R. A.; Mohan, V.; Rao, G.; Pal, A.; Pathak, A.; Singh, M.; Godbole, M. M., Effect of hypothyroxinemia on thyroid hormone responsiveness and action during rat postnatal neocortical development. Experimental neurology 2011, 228 (1), 91-8. DOI: 10.1016/j.expneurol.2010.12.012.
  52. Sinha, R. A.; Pathak, A.; Mohan, V.; Babu, S.; Pal, A.; Khare, D.; Godbole, M. M., Evidence of a bigenomic regulation of mitochondrial gene expression by thyroid hormone during rat brain development. Biochemical and biophysical research communications 2010, 397 (3), 548-52. DOI: 10.1016/j.bbrc.2010.05.154.
  53. Sinha, R. A.; Pathak, A.; Kumar, A.; Tiwari, M.; Shrivastava, A.; Godbole, M. M., Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75(NTR). Molecular and cellular neurosciences 2009, 40 (3), 354-64. DOI: 10.1016/j.mcn.2008.12.001.
  54. Sinha, R. A.; Khare, P.; Rai, A.; Maurya, S. K.; Pathak, A.; Mohan, V.; Nagar, G. K.; Mudiam, M. K.; Godbole, M. M.; Bandyopadhyay, S., Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2009, 27 (4), 377-83. DOI: 10.1016/j.ijdevneu.2009.02.003.
  55. Tiwari, M.; Bajpai, V. K.; Sahasrabuddhe, A. A.; Kumar, A.; Sinha, R. A.; Behari, S.; Godbole, M. M., Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells. Carcinogenesis 2008, 29 (3), 600-9. DOI: 10.1093/carcin/bgm264.
  56. Sinha, R. A.; Pathak, A.; Mohan, V.; Bandyopadhyay, S.; Rastogi, L.; Godbole, M. M., Maternal thyroid hormone: a strong repressor of neuronal nitric oxide synthase in rat embryonic neocortex. Endocrinology 2008, 149 (9), 4396-401. DOI: 10.1210/en.2007-1617.
  57. Kumar, A.; Sinha, R. A.; Tiwari, M.; Singh, R.; Koji, T.; Manhas, N.; Rastogi, L.; Pal, L.; Shrivastava, A.; Sahu, R. P.; Godbole, M. M., Hyperthyroidism induces apoptosis in rat liver through activation of death receptor-mediated pathways. Journal of hepatology 2007, 46 (5), 888-98. DOI: 10.1016/j.jhep.2006.12.015.
  58. Tiwari, M.; Kumar, A.; Sinha, R. A.; Shrivastava, A.; Balapure, A. K.; Sharma, R.; Bajpai, V. K.; Mitra, K.; Babu, S.; Godbole, M. M., Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress. Carcinogenesis 2006, 27 (10), 2047-58. DOI: 10.1093/carcin/bgl051.
  59. Shrivastava, A.; Tiwari, M.; Sinha, R. A.; Kumar, A.; Balapure, A. K.; Bajpai, V. K.; Sharma, R.; Mitra, K.; Tandon, A.; Godbole, M. M., Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. The Journal of biological chemistry 2006, 281 (28), 19762-71. DOI: 10.1074/jbc.M600746200.
  60. Kumar, A.; Sinha, R. A.; Tiwari, M.; Pal, L.; Shrivastava, A.; Singh, R.; Kumar, K.; Kumar Gupta, S.; Godbole, M. M., Increased pro-nerve growth factor and p75 neurotrophin receptor levels in developing hypothyroid rat cerebral cortex are associated with enhanced apoptosis. Endocrinology 2006, 147 (10), 4893-903. DOI: 10.1210/en.2006-0027.