Publications and Presentations

Wellcome-DBT IA funded publications:

14. Gupta R and Laxman S* (2019). tRNA wobble-uridine modifications as amino acid sensors and regulators of cellular metabolic state.

Current Genetics doi: 10.1007/s00294-019-01045-y


13. Walvekar A and Laxman S* (2019). Methionine at the Heart of Anabolism and Signaling: Perspectives From Budding Yeast.
Frontiers in Microbiology 10:2624 doi: 10.3389/fmicb.2019.02624

12. Shaw E, Talwadekar M, Rashida Z, Mohan N, Acharya A, Khatri S, Laxman S, Kolthur-Seetharam U (2019).
Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria.
In press Molecular and Cellular Biology doi: 10.1128/MCB.00212-19


11. Vengayil V, Rashida Z, Laxman S* (2019). The E3 Ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown upon glucose availability.

J. Biol. Chem.


10. Gupta R, Walvekar AS, Liang S, Rashida Z, Shah P, Laxman S* (2019). A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis.

Elife. 2019 Jul 1;8. pii: e44795. doi: 10.7554/eLife.44795. Pubmed link.

Elife Digest.


9. Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S* (2019). Metabolic constraints drive self-organization of specialized cell groups.

Elife. 2019 Jun 26;8. pii: e46735. doi: 10.7554/eLife.46735. Pubmed link.

Elife Digest.


8. Walvekar A, Srinivasan R, Gupta R and Laxman S* (2018). Methionine coordinates a hierarchically organized anabolic program.
Molecular Biology of the Cell. 2018, 29(26):3183-3200 Pubmed link
Selected as "A Highlights from MBoC Selection"

7. Walvekar A*, Rashida Z, Maddali H and Laxman S* (2018). A versatile LC-MS/MS approach for comprehensive, quantitative analysis of central metabolic pathways. Wellcome Open Res 2018, 3:122 Pubmed link

6. Krishna S* and Laxman S*. (2018) A minimal "push-pull" bistability model explains oscillations between quiescent and proliferative cell states.

Molecular Biology of the Cell. 2018, 29(19):2243-2258 Pubmed link
Selected as "A Highlights from MBoC Selection"

5. RVR Choudhury, A Prabhakar, Laxman S* (2017) Optofluidic platform to investigate cell community behavior in microenvironments,
Life Sciences Conference (LSC), 2017 IEEE, 51-54
PDF link

4. Deshpande AA, Bhatia M, Laxman S*, Bachhawat AK* (2017). Thiol trapping and metabolic redistribution of sulfur metabolites enable cells to overcome cysteine overload

Microbial Cell, 2017, Vol. 4, No. 4, pp. 112 - 126. Pubmed link

3. Laxman S* (2017). Conceptualizing Eukaryotic Metabolic Sensing and Signaling.

J Indian Institute of Science, 2017, 97(1):59-77 Pubmed link


2. Erkut C, Gade VR, Laxman S and Kurzchalia TV (2016). The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast.

  Elife 2016;5:e13614 Link


1. Dhawan J and Laxman S*  (2015). Decoding the stem cell quiescence cycle: lessons from yeast for regenerative biology.

J Cell Sci Dec 15 2015, 128: 4467-4474. Link.


Other publications (postdoctoral and graduate work):

1. Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu BP, MacMillan JB, Brabander JKD, Veech RL and Uyeda K, “Metabolite Regulation of Nuclear Localization of Carbohydrate Response Element-binding Protein (ChREBP). Role of AMP as an Allosteric Inhibitor.” J. Biol. Chem 2016 May 13;291(20):10515-27.

2. Dutchak PA, Laxman S, Estill SJ, Wang C, Bulut GB, Gao J, Huang LJ and Tu BP, “Regulation of Hematopoiesis and Methionine Metabolism by mTORC1 Inhibitor NPRL2.” Cell Reports Volume 12, Issue 3, 21 July 2015, Pages 371–379.

3. Laxman S, Sutter BM and Tu BP, “Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites.” Science Signaling Vol 7 Issue 356 ra120, December 2014

Interview in Science Signaling podcast

Description of cover image (about story)

4. Laxman S, Tu BP and McKnight SL, “Concerted effort: Oscillations in global gene expression during nematode development”, Molecular Cell 53, 363-364, February 6 2014 (invited Preview for Hendriks et al, same issue of Molecular Cell)

5. Laxman S, Sutter BM & Tu BP “Methionine is a signal of amino acid sufficiency that inhibits regulates NNS-autophagy through the methylation of PP2A”, Invited “Autophagic Puncta” for Autophagy Volume 10, Issue 2, February 2014, pg 386-387

6. Laxman S, Sutter BM, Wu X, Kumar S, Xiaofeng Guo, David C. Trudgian, Hamid Mirzaei and Tu BP, “Sulfur amino acids regulate cellular translational capacity through modulation of tRNA wobble-uridine thiolation” Cell, Volume 154, Issue 2, 416-429, 18 July 2013

Comment in: Science Signal., 23 July 2013, Vol. 6., Issue 285, p ec170 (Editor’s choice).

F1000 Prime recommended (exceptional)

7. Sutter BM, Wu X, Laxman S, and Benjamin P. Tu, “Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A.” Cell, Volume 154, Issue 2, 403-415, 18 July 2013

Comment in: Science Signal., 23 July 2013, Vol. 6., Issue 285, p ec170 (Editor’s choice).

8. Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT, “Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase”, Proceedings of the National  Academy of Sciences U.S.A. 2013 Jun 11;110(24):9728-33.

9. Laxman S* & Tu BP*, “Nitrogen starvation-dependent cellular differentiation in S. cerevisiae is controlled by multiple TORC1 components”, PlosOne 2011; 6(10): e26081

10. Laxman S & Tu BP, “Systems approaches for the study of metabolic cycles in yeast”. Current Opinion in Genetics and Development, 2010 Dec;20(6):599-604

11. Laxman S, Sutter B and Tu BP, “Behavior of a Metabolic Cycling Population at the Single Cell Level as Visualized by Fluorescent Gene Expression Reporters” PLoS One 2010 Sept 7; 5(9): e12595

12. Laxman S* and Beavo JA, “Cyclic nucleotide signaling in Trypanosomes: possible target for therapeutic agents?” Molecular Interventions 2007 Aug;7(4):203-15

Cover article.

13. Laxman S, Riechers A, Sadilek M, Schwede F and Beavo JA, "Hydrolysis products of cAMP analogs cause slender to stumpy transformation in T. brucei”, Proceedings of the National Academy of Sciences U.S.A. 2006 Dec 12; 103(50): 19194-19199.

Comment in: “In This Issue”, PNAS 2006 Dec 12; 103(50): 18877-19214

14. Diaz-Benjumea R#, Laxman S#, Hinds TR, Beavo JA, and Rascon A., “Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi”, Biochemical Journal. 2006 Oct 15;399(2):305-14.

#co-first authors, listed alphabetically

15. Kunz S, Beavo JA, D'Angelo MA, Flawia MM, Francis SH, Johner A, Laxman S, Oberholzer M, Rascon A, Shakur Y, Wentzinger L, Zoraghi R, Seebeck T., “Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature”, Mol Biochem Parasitol.  2006 Jan;145(1):133-5.

16. Laxman S, Rascon A and Beavo JA, "Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain".  The Journal of Biological Chemistry. 2005 Feb 4;280(5):3771-9.