Publications and Presentations


Corresponding author*

Primary Research Papers

  1. Sharma S, Mathre S, Ramya V, Shinde S, Raghu P. Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling. Cell Rep. 2019 May 14;27(7):1991-2001.e5. doi: 10.1016/j.celrep.2019.04.070
  2. Panda A, Thakur R, Krishnan H, Naik A, Shinde D, Raghu P*. Functional analysis of mammalian phospholipase D enzymes. Biosci Rep. 2018 Oct 28. pii: BSR20181690. doi: 10.1042/BSR20181690. [Epub ahead of print]
  3. Balakrishnan SS, Basu U, Shinde D, Thakur R, Jaiswal M, Raghu P*. Regulation of PI4P levels by PI4KIIIα during G-protein coupled PLC signaling in Drosophila photoreceptors. J Cell Sci. 2018 Jul 6. pii: jcs.217257. doi: 10.1242/jcs.217257.
  4. ADBS consortium paper (P. Raghu member of consortium). Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science. BMC Psychiatry. 2018.
  5. Suratekar R, Panda A, Raghu P & Krishna S. Evidence of sinks and sources in the phospholipase C?activated PIP2 cycle. FEBS. Lett. 2018.
  6. Ashe S, Malhotra V and Raghu, P*. Protein kinase D regulates metabolism and growth by controlling secretion of insulin like peptide. Dev.Biol, 2017.
  7. Yadav S, Thakur R, Georgiev P, Deivasigamani S, Ratnaparkhi G and Raghu P*. FFAT/VAP interaction imposes intramolecular regulation on lipid transfer function at membrane contact sites. J. Cell. Sci, 2017: jcs.207985 doi: 10.1242/jcs.207985 
  8. Kamalesh K, Trivedi D, Toscano S, Kolay, S, Sharma, S and ­­­Raghu P*. Phosphatidylinositol 5-phosphate 4-kinase regulates clathrin mediated endocytosis in developing Drosophila photoreceptors J. Cell. Sci, 2017; 130: 2119-2133; doi: 10.1242/jcs.202259.
  9. Thakur RS, Panda A, Coessens E, Raj N, Yadav S, Balakrishnan S, Zhang Q, Georgiev P, Basak B, Pasricha R, Wakelam MJO, Ktistakis N and Raghu P*. Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling. eLife. 2016 5:e18515. DOI: 10.7554/eLife.18515.
  10. Choudhury SD, Mushtaq Z, Reddy-Alla S, Balakrishnan SS, Thakur RS, Krishnan KS, Raghu P, Ramaswami M, Kumar V. σ2-adaptin Facilitates Basal Synaptic Transmission and Is required for Regenerating Endo-Exo Cycling Pool under High Frequency Nerve Stimulation in DrosophilaGenetics. 2016;203(1):369-85. doi: 10.1534/genetics.115.183863. 
  11. Yadav, S., Garner, K., Georgiev, P., Li, M., Gomez Espinosa, E., Panda, A., Mathre, M., Cockcroft, S and Raghu, P*. RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction. J.Cell.Sci. 2015; 128:3330-3344
  12. Chakrabarti, P., Kolay, S., Yadav, S, Kamalesh Kumari, K., Nair, A., Trivedi, D and Raghu, P*. A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors. PLOS Genetics. 2015; 11(1):e1004948. doi: 10.1371/journal.pgen.1004948. eCollection 201
  13. Lowe, N, Rees, J and the UK Drosophila Protein Trap Screening [email protected] Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Development 2014 141, 3994-4005. @Raghu P member of Consortium.
  14. Gupta, A, Sarah Toscano, S, Trivedi, D, Jones DJ, Mathre S, Clarke J, Georgiev P, Divecha N and Raghu P*. Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signalling and cell growth during Drosophila development. Proc. Natl. Acad. Sci. USA 2013;110 (15):5963-8
  15. Chu BLiu CHSengupta SGupta ARaghu PHardie RC. Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors. J Neurophysiol. 2013; 109(8):2044-55
  16. Badsha F, Kain P, Prabhakar S, Sundaram S, Raghu P, Rodrigues V, Hasan G. Mutants in Drosophila TRPC Channels Reduce Olfactory Sensitivity to Carbon Dioxide. PLoS One. 2012; 7(11): e49848.
  17. Garner K, Hunt AN, Koster G, Somerharju P, Groves E, Li M, Raghu P, Holic R, Cockcroft S. Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers Phosphatidic Acid. J.Biol.Chem. 2012; 287(38): 32263-7.
  18. Georgiev P, Toscano S, Nair A, Hardie R, Raghu P*. Identification of a suppressor of retinal degeneration in Drosophila photoreceptors. J. Neurogenet. 2012 (3-4): 338-47.
  19. Georgiev, P., Okkenhaug, H, Drews, A, Wright, D., Flick, M, Lambert, S, Oberwinkler, J and Raghu, P*. TRPM channels mediate zinc homeostasis and cellular growth during Drosophila larval development. Cell Metabolism. 2010; 12, 386–397
  20. Raghu, P*, Coessens E, Manifava M, Georgiev P, Pettitt T, Wood E, Garcia-Murillas I, Okkenhaug H, Trivedi D, Zhang Q, Razzaq A, Zaid O, Wakelam MJO, O'Kane CJ, Ktistakis NT Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels. J. Cell.Biol. 2009; 185 129-145.
  21. Garcia-Murillas I, Pettit T, Macdonald E, Okkenhaug H, Georgiev P, Trivedi D, Hassan B, Wakelam M and Raghu, P*. lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction. Neuron. 2006. 29:4, 533-546.
  22. Georgiev, P, Garcia-Murillas, I, Ulahannan, D Hardie, R.C and Raghu, P*. Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.”  J.Cell.Sci. 2005. 118:1373-1384
  23. Hardie, R.C, Gu, Y., Martin, M., Sweeney, S.T and Raghu, P. In Vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1) J. Biol. Chem. 2002 279: 47773 – 47782
  24. Hardie, RC, Martin F, Chyb S and Raghu, P. Rescue of light responses in the Drosophila "null” phospholipase C mutant, norpAP24 by diacylglycerol kinase mutant, rdgA and by metabolic inhibition. J. Biol. Chem. 2003; 278: 18851 – 18858
  25. Hardie, R.C., Martin, F., Cochrane, G.R., Jussola, M.G, Georgiev, P & Raghu, P. Molecular basis of amplification in Drosophila phototransduction: roles for G-protein, phospholipase C and diacylglycerol kinase. Neuron. 2002 36: 689-701.
  26. Hardie, R.C, Raghu, P, Moore, S, Juusola MBaines RASweeney ST, Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron.  2001; 30: 1-20.
  27. Raghu, P, Usher, K.R, Jonas SChyb SPolyanovsky AHardie, Constitutive activity of the light sensitive channels, TRP and TRPL, in the Drosophila diacylglycerol kinase mutant, retinal degeneration A (rdgA) . Neuron. 2000. 26: 169-179.
  28. Raghu, P, Colley,N.J, Webel, R, James THasan GDanin MSelinger ZHardie RC. Normal phototransduction in Drosophila photoreceptors lacking an InsP3 receptor. Mol. Cell. Neurosci. 2000; 15: 429-445.
  29. Chyb, S, Raghu, P & Hardie, R.C. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature. 1999. 397: 255-259
  30. Hardie, R.C. & Raghu, P. Activation of heterologously expressed Drosophila TRPL channels: Ca2+ is not required and InsP3 is not sufficient. Cell Calcium. 1998; 24(2): 153-163.
  31. Raghu, P., Habib, S., Hasnain, E. & Hasan, G. Development of a functional assay for Ca2+ release activity of IP3R and expression of an IP3R gene fragment in the baculovirus-insect cell system. Gene. 1996; 190:151-156.
  32. Raghu, P. & Hasan G. The inositol 1, 4, 5 trisphosphate receptor expression in Drosophila suggests a role for IP3 signalling in muscle development and adult chemosensory function. Dev.Biol. 1995; 171:564-577.



  1. Thakur R, Naik A, Panda A and Raghu P. Regulation of membrane turnover by phosphatidic acid: cellular functions and disease implications. Fron. Cell Devl. Biol 2019 Jun 4;7:83. doi: 10.3389/fcell.2019.00083. eCollection
  2. Cockcroft S, Raghu P. Phospholipid transport protein function at organelle contact sites. Curr Opin Cell Biol. 2018 Aug; 53:52-60. doi: 10.1016/ Epub 2018 May 30.
  3. Topological organisation of the phosphatidylinositol 4,5-bisphosphate-phospholipase C resynthesis cycle: PITPs bridge the ER–PM gap. Cockcroft S and Raghu P. Biochemical Journal (2016) Dec 1;473(23):4289-4310
  4. RdgBα reciprocally transfers PA and PI at ER-PM contact sites to maintain PI(4,5)P2 homoeostasis during phospholipase C signalling in Drosophila photoreceptors. Cockcroft S, Garner K, Yadav S, Gomez-Espinoza E, Raghu P. Biochem Soc Trans. (2016) Feb 15;44(1):286-92. doi: 10.1042/BST20150228.
  5. The Drosophila photoreceptor as a model system for studying signalling at membrane contact sites. Yadav S, Cockcroft S and Raghu P*. Biochem Soc Trans. (2016) Apr 15;44(2):447-51. doi: 10.1042/BST20150256
  6. Control of diverse sub-cellular processes by a single multi-functional lipid phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2]. Kolay, S., Basu, U and Raghu, P*. Biochemical Journal. (2016) Jun 15;473(12):1681-92. doi: 10.1042/BCJ20160069.
  7. Balakrishnan SSBasu URaghu P*. Phosphoinositide signalling in Drosophila. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids; Phosphoinositide Signalling (2014) Oct 30. pii: S1388-1981(14)00219-4
  8. Raghu, P*., Yadav, S and Mallampati, N. Lipid signalling in Drosophila photoreceptors. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. Vesicular Transport. 2012; 1821(8):1154-65.
  9. Raghu P, Hardie RC. Regulation of Drosophila TRPC channels by lipid messengers. Cell Calcium. 2009; 45(6): 566-73.
  10. Raghu, P, Manifava M, Coadwell WJ, Ktistakis NT. Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors). Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 2009; 1791(9):889-97
  11. Trivedi D and Raghu P*. RdgB proteins; functions in lipid homeostasis and signal transduction. BBA; Molecular and Cell Biology of Lipids. 2007. 1771:692-699.
  12. Raghu, P. Regulation of Drosophila TRPC channels by protein and lipid interactions. Semin Cell Dev Biol 2006. 17(6):646-653
  13. Raghu, P* and Andrews, S (TRP channels at a glance. J.Cell.Sci. 2004. 117:5707-5709
  14. Raghu, P*. LPP2. AfCS-Nature Molecule Pages (2005). doi: 10.1038/mp.a003072.0
  15. Hardie, R.C. & Raghu, P. Visual transduction in Drosophila. Nature. 2001; 413:186-193.

Book Chapters

  1. Dolph, P, Nair, A and Raghu, P*. Analysis of visual physiology in the adult Drosophila eye. Book chapter in Drosophila Neurobiology Methods: A Laboratory Manual. Cold Spring Harbor Laboratory Press. 2010; Chapter 14. 225-235.


  1. Avishek Ghosh, Sanjeev Sharma, Dhananjay Shinde, Visvanathan Ramya, Padinjat Raghu A novel mass assay to measure phosphatidylinositol-5-phosphate from cells and tissues. bioRxiv 707604; doi: