Research Summary

Structural & functional connectivity of hippocampus in Schizophrenia: evaluation of neuroimmunological & neurotrophic factors interactions using diffusion tensor imaging & functional magnetic resonance imaging studies

Schizophrenia is complex neuropsychiatric disorder is characterized by delusions, hallucinations, disorganized behaviour and progressive cognitive deficits, whose pathophysiology remains unclear. It is ranked among the top ten disabling disorders by the World Health Organization. A compelling hypothesis with translational potential, investigated in the senior fellowship research, is that “complex interactions between neuroimmunological / neutrophic factors and hippocampus might underlie the pathogenesis of schizophrenia”. Ascertaining evidence for these pathogenetic interactions will enhance our understanding of this intriguing disorder and can potentially open novel therapeutic targets for schizophrenia.