Research Summary

Size abt birth , risk factors across life and cognition in late life: A lifecourse epidemiology study of the Mysore Birth Records Cohort.

For late-life neurocognitive disorders, as for other late life chronic diseases, much of the interest has focused upon the possible relevance of Developmental Origins of Health and Disease (DOHaD) with programming by under nutrition in very early life exacerbated by over nutrition in later life leading to an increased risk, mediated through cardiovascular and metabolic pathways. The purpose of the proposed project is to establish a late-life cognitive baseline, to begin to explore pathways from early life growth and development to late-life impairment and decline. This study will specifically examine if intra-uterine growth restriction is associated with poorer cognitive functioning in late-life.

Survivors of the Mysore birth cohort, India aged above 60yrs (n=715) will be asked to participate in a one phase baseline assessment. I plan to use a battery of cognitive tests (developed and normed in India) and other validated assessments that will allow me to assess mental disorder, chronic disease impairments and disabilities, nutritional status, health behaviours and lifestyles, family living arrangements, economic status, social support and social networks. Investigations will include blood tests (for dyslipedemia, insulin-resistance, diabetes, anaemia, and thyroid disease), anthropometry, ECG, blood pressure assessment and genetic assay for Apoliprotein-E. This study will add to the scientific understanding of early life programming of late life neurocognitive disorders.

Figure Legend: Images of the Mysore Birth Cohort and CSI Holdsworth Memorial Hospital.