Research Summary

Understanding mechano-sensing and the role of mechano- signals in determining stem cell fate

Which comes first, form or function? How different organs get their particular shape during embryonic development? Are cells, the units of life, governed by only genetics and bio-chemicals? Do mechanics and physics play important roles in controlling cell behaviour? If yes, how? How do cells respond to the mechanical properties of their environment? Why do in many diseased conditions, including cancer, these responses get severely modified? These are the central questions of my research. We work with materials of different mechanical and geometric properties and ask the question how material property of the surrounding environment governs stem cell functioning. Understanding how cells perceive their surroundings and how they react are essential to take our present day knowledge about stem cells from lab to clinic, to design an efficient cell delivery system and scaffolds.