Research SummaryIntermediate Fellowship research summary
One of the central questions in developmental biology is to try and understand how cells get their positional identity during development. My broad research interest lies in understanding the molecular basis of this phenomenon in context of developing central nervous system (CNS) of Drosophila melanogaster. More specifically I am interested in understanding how a family of transcription factors known as Hox genes play a role in giving specific positional identity to neural stem cells (NSCs) along the anterior posterior (AP) axis of the developing CNS. The precise molecular mechanism by which Hox genes differentially control the properties of NSCs during early developmental stages to generate a diversity of cell types along the AP axis of CNS remains poorly understood in both vertebrates and invertebrates. Since underlying principles of CNS patterning and development are broadly conserved studies done in Drosophila will be relevant in a wider context.