Research SummarySenior Fellowship research summary
Hematopoietic stem cells (HSCs), like other adult stem cells, reside in special microenvironments known as niches. Cues from the niche cells maintain an intricate balance between proliferation-inhibiting and proliferation-promoting signals that regulates stem cell maintenance versus tissue regeneration. Maintenance of hematopoetic niches is therefore very critical for HSC state and fate.
Although much attention is being paid to understand the role of niche cells in regulating the HSCs, very limited information is available about the mechanism that controls the niche cells.
We are employing Drosophila as a model system to study the Regulatory Circuitry involved in maintaining the homeostasis and physiological responses of blood cells and hematopoietic niche,