Research Summary

Intermediate Fellowship Research Summary

Inhibitory circuits in the brain play a crucial role in sensory processing, plasticity and development. Altered inhibitory function causes profound changes in the brain and is associated with diseases such as epilepsy, cerebral palsy, attention deficit and altered perception. Especially in the auditory cortex, little is known about the precise role of inhibition in cortical micro-architecture and its development, processing and mediation of top down plasticity to form finer percepts in varying natural environment. The proposed study, using electrophysiology and imaging, aims to understand function of inhibitory circuits in the auditory cortex and lays the groundwork for identifying common principles of action of inhibition in the brain leading to knowledge of understanding auditory perception and how inhibitory mechanisms mediate online supervisory inputs that change auditory processing in a goal directed manner. It also leads to understanding causes of auditory deficits in hearing loss, attention deficit and other diseases that are associated with disruption of inhibition in cortical networks.

Anterograde labeled terminals (green) of projections from mouse orbitofrontal cortex to auditory cortex including parvalbumin positive inhibitory neurons (red).