Research SummaryPersonalized therapy of esophageal squamous cell carcinoma by targeting activated kinases
Esophageal squamous cell carcinoma is one of the leading cause of cancer deaths in the world. The incidence and mortality rate of ESCC is particularly high in developing countries like India and China. High mortality rate in ESCC has been attributed to late clinical presentation of the disease and lack of effective therapy.
Several studies on various cancers have firmly established the role of aberrantly regulated kinase signaling pathways in driving cancers. Therapies targeting tyrosine kinase signaling pathways that drive cancer cell proliferation have emerged as a promising strategy to treat various cancers. My proposed research will probe into aberrant activation of serine/threonine kinase and tyrosine kinase signaling pathways in esophageal squamous cell carcinoma. To achieve this, I will carry out global phosphoproteomic profiling of esophageal squamous cell carcinoma by employing mass spectrometry based quantitative proteomic strategy. Aberrantly regulated kinase signaling pathways in neoplastic condition as compared to non-neoplastic condition will be determined and the effect of targeted inhibition of these pathways on cancer development will be investigated. These studies have the potential to contribute immensely towards developing targeted therapeutic strategies to treat esophageal squamous cell carcinoma.