Research Summary

Intermittent Theta Burst Stimulation of Cerebellar Vermis in Schizophrenia: Impact on Negative Symptoms and Brain Connectivity


 Dr. Rakshathi Basavaraju                              Dr. Muralidharan K.                                        Dr. Arvinda HR.   

 Research Training Fellow                             Principal Supervisor                                          Co-Supervisor                              


                 Host Institution                                                 Institution                                                       Institution                                     

 National Institute of Mental Health           National Institute of Mental Health             National Institute of Mental Health

    And Neurosciences, Bangalore                 And Neurosciences, Bangalore                      And Neurosciences, Bangalore


Theta Burst Stimulation (TBS) is a novel patterned repetitive transcranial magnetic stimulation (rTMS) technique whose safety and efficacy has been established in a small group of schizophrenia patients in an open label study. The aims of our study is to examine the efficacy of iTBS (intermittent TBS) to the cerebellar vermis for negative symptoms in schizophrenia, to examine the resting state functional connectivity correlates of clinical improvement in negative symptoms and cognitive deficits. It would be a double-blind randomized controlled trial, where 60 patients of schizophrenia meeting inclusion and exclusion criteria will be randomized to intervention arm who will receive iTBS and control arm who will receive sham TMS (30 in each group). A resting state functional MRI will be obtained at baseline and at the end of the iTBS sessions. Patients will receive iTBS or sham-TMS for 5 days under MRI guided neuronavigation (two-sessions a day, four hours apart).