Research SummaryInvestigating the mechanism of mechanostress induced ATR activation and its role in cell plasticity regulation
The DNA damage response is mediated mainly by ATR to govern genome integrity of replicating chromosomes. Recent advances also suggest ATR involvement in a wide range of cellular processes independent of DNA damage. These new functions of ATR may explain the basis of defects observed in ATR associated Seckel syndrome. However, the mechanisms underlying the disease are still poorly understood. For this reason, I would like to investigate weather ATR is an integral part of cell regulatory pathways that contributes to the maintenance of NE integrity, chromosome fragile sites and cell plasticity.