Research Summary

Investigating the role of nicotinic neuromodulation in levodopa-induced dyskinesias - a multimodal study

The primary focus of my laboratory is to explore the pathophysiology of movement disorders using multimodal neurophysiological methods such as transcranial magnetic stimulation (TMS), electromyography (EMG), electroencephalography (EEG), magnetoencephalography (MEG) and local field potentials (LFP). I will specifically explore changes in motor neuroplasticity and functional connectivity in the motor network, and their clinical/behavioral relevance in patients with movement disorders.

The current project funded by Wellcome Trust/DBT India Alliance is aimed at determining the role of nicotinic neuromodulation in the pathophysiology of levodopa-induced dyskinesias. Levodopa is the gold-standard drug available to treat Parkinson’s disease. However, over time, most patients develop abnormal involuntary movements called levodopa-induced dyskinesias (LID) as a complication. Animal experiments have proposed nicotine to be a potential drug for LID but its mechanism of action is unclear. Integrating non-invasive brain stimulation and recording methods, I will determine if nicotine can reverse certain abnormalities of brain function that are specific to Parkinsonian patients with LID. The results of this project will help in understanding the role of nicotine in the disease process and in evaluating nicotine as a promising treatment for LID.


Open positions:

Applications are invited from eligible candidates, for filling up of the following posts on CONTRACT basis at NIMHANS, Bengaluru:

I.        Name of the Post: Project Assistant

Essential qualification: MBBS or Master’s degree in life sciences/ neuroscience or related field

Desirable qualification: Clinical research experience, Clinical experience in neurology

Maximum age limit:    30 years

Emoluments:   Rs.25,000/- + 30% HRA per month

Duration of the post:   2 years (The initial appointment will be made for 6 months, which will be renewed yearly for up to 2 years subject to satisfactory performance of the candidate)

II.        Name of Post: Research Fellow

Essential qualification: MBBS or Master’s degree in basic sciences/ neuroscience/any technical field or Bachelor’s degree in engineering with programming experience. Candidates who are interested to register for PhD may apply.

Desirable qualification: JRF awardee (ICMR/CSIR/DBT/UGC); Experience with biomedical/neural signal processing; Programming with MATLAB; Prior research experience with a publication record in peer-reviewed journals.

Maximum age limit:    30 years

Emoluments:   Rs.25,000/- + 30% HRA

Duration of the post:   2 years (the initial appointment will be for 6 months which will be extendable annually for the duration of the project subject to satisfactory performance of the candidate). The candidate may have an opportunity to register for PhD if interested.

Candidates are requested to submit their curriculum vitae, age proof, copy of testimonials and a statement of purpose (summarizing your educational and research experience, motivation, professional interests, career goals and aspirations in not more than 1 page). Copies of any peer-reviewed publications should also be submitted.

Applications should be submitted through email to [email protected].

Last date for receipt of applications along with relevant documents is 15.10.2017.