Research Summary

Understanding Neural Correlates of Music and Rhythm Perception and the effect of Indian Music and Rhythm Based Cognitive Remediation in Parkinson's Disease

Parkinson’s disease (PD) is the second most common degenerative disorder. Along with motor symptoms, non-motor symptoms (NMS) like cognitive and emotion deficits, depression, anxiety, sleep disturbances contribute significantly to disability and quality of life in PD patients. Cognitive rehabilitation (CR) is emerging as one of the accepted non-pharmacological method to treat cognitive deficits. There is a strong need for comprehensive method of cognitive rehabilitation method that can target cognition, emotion and motor functions which is implicated in PD. Music has the potential to offer significantly in rehabilitation targeting motor and NMS in PD.

The study will be carried out in two phases. Phase 1 – the aim is to examine the cognitive profile, music, rhythm perception and emotion perception in patients with PD compared to matched healthy controls using resting state fMRI and task-based fMRI. Phase 2 – the aim of this randomized controlled study is to examine the effects of three-month long Indian music and rhythm based cognitive remediation program as an add-on treatment in PD patients. The aim is also to study the underlying neural correlates post intervention and observe the sustenance of improvement after 6-month. Music and rhythm based activities are considered powerful methods to facilitate neuralplasticity, the veritable nature of the brain and the principle on which CR is based.