Recently recommended Grants Awardees 2019 for Team Science & Clinical Research Centres
31 Jan 2020
In April 2019, we launched new funding programmes to support collaborative and interdisciplinary research projects, clinical research centres, and clinical research training with an aim to promote excellence and innovation and enhance India’s health research ecosystem.
Team Science Grants (TSG) fund teams that bring together high-quality scientists from multiple institutions with complementary skills, knowledge, and resources to address an important health challenge for India. Clinical/Public Health Research Centres (CRC) are envisioned as ‘research-oriented centres’, which preferably involve multiple institutions that focus on important biomedical research problems and develop physician scientists. The CRCs have an embedded Clinical Research Training Programme (CRTP) to anchor the development of physician-scientists.
The Wellcome Trust/DBT India Alliance announces Recently Recommended Awardees for Team Science Grants and Grants for Clinical/Public Health Research Centres.
TEAM SCIENCE GRANTS
Grant Title: Longitudinal effects of Air Pollution Exposures on Lung growth and development of biomarker of lung function deficit in Urban Children
Lead Principal Investigator: Dr. Mahesh Padukudru Anand, JSS Medical College, India
- Dr Anant Mohan, All India Institute of Medical Sciences, New Delhi.
- Dr George D’Souza, St Johns National Academy of Health Sciences, Bangalore
- Dr Harish Phuleira, Indian Institute of Technology-Bombay, Mumbai
- Dr Rajesh K ThimmulappaJSS Medical College, Mysore
- Dr Gregory A Wellenius, Brown University, USA
Studies from USA and Europe find that a significant proportion of children in communities with high air pollution levels have poor lung development, which leads to significant deficit in peak lung function as they reach to young adulthood (18-22yr). Lower lung function in young adults dramatically increases risk for COPD and heart diseases. The air pollution across Indian cities is several times higher than Western world. However, its impact on lung development in children in India is not known. This project will study lung development in children living in Mysore, Mumbai, Bangalore and Delhi to find the adverse impact of rising air pollution.
Grant Title: Developing broadly neutralizing monoclonal antibody mediated prevention and treatment strategy by assessing their effectiveness in neutralizing HIV‐1 subtype C circulating in India across different regions and distinct risk groups.
Lead Principal Investigator: Dr. Jayanta Bhattacharya, Translational Health Science and Technology Institute, India
- Dr Vainav Patel, ICMR-National Institute for Research in Reproductive Health, Mumbai
- Dr Shanmugam Saravanan, Y.R. Gaitonde Medical, Educational and Research Foundation, Chennai
Integrated disease management approaches are increasingly promoted as a means of improving effectiveness and efficiency of healthcare for chronic diseases such as HIV/AIDS. Novel anti‐HIV broadly neutralizing monoclonal antibodies (bNAbs) hold promise in the prevention and treatment of HIV‐1n infection. Hence to develop an effective bnAbs based preventive & therapeutic solution for HIV, it becomes critical to assess people living with HIV (PLHIV) categorized into dissect risk groups, ethnicity with and without comorbidities. Through the proposed study, investigators aim to assess the potential of lead bnAbs as product for prevention and therapy in the context of Indian subtype C viruses.
CLINICAL/PUBLIC HEALTH RESEARCH CENTRE GRANTS
Grant Title: Role of protein and vitamin B12 in clinical and public health nutrition in India
Lead Principal Investigator: Prof. Anura Kurpad, St. John’s Medical College
- Prof. Harshpal Singh Sachdev, Sitaram Bhartia Institute of Science and Research
- Prof. Tinku Thomas, St. John’s Medical College
- Prof. Rebecca RajSt. John’s Medical College
Since Indian diets are cereal-based, they lack quality foods like pulses, milk, egg, fruits and vegetables. Poor intake of these foods results in poor child growth, low muscle mass and the risk of adult diabetes. During breast feeding, we need to understand how the mother’s food intake influences her breast milk, and along with later home foods, influences her baby’s growth. Vitamin B12 comes from animal source foods like milk and meat and is very low in vegetarian India. When low B12 intakes co-exist with gut problems, measuring absorption is important. In this project, three vertical activities are proposed, using deep-phenotyping and innovative statistical methods, to evaluate the role of these nutrients specific to public health problems. The knowledge gained in this project will be translated to public health actions by examining national surveys.
Grant Title: Centre for Health Outcomes Research and Economics (CHORE)
Lead Principal Investigator: Dr Raja Narayanan, LV Prasad Eye Institute
- Dr Anthony Vipin Das, L.V. Prasad Eye Institute, Hyderabad
- Prof. Chirantan Chatterjee, Indian Institute of Management, Ahmedabad
- Dr GVS Murthy, Indian Institute of Public Health, Hyderabad
LV Prasad Eye Institute has digitised all its patient records of over 30 years into a single Electronic Medical Record system. This is automatically updated with information from new patients and contains both economic related as well as the medical information of every patient ever seen in any LVPEI network hospital. Using this data and by mining for relevant information, it proposes to address important economic and public health related questions for improving interventions and policy in eye care. It aims to generate new knowledge in clinical research and develop a training centre for clinicians to assess and perform research, evaluate cost-effectiveness of services and interventions, and analyse big data. It partners with IIM, Ahmedabad and IIPH, Hyderabad in this endeavour.